ID F7FJA4_ORNAN Unreviewed; 1612 AA.
AC F7FJA4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Collagen type IV alpha 3 chain {ECO:0000313|Ensembl:ENSOANP00000017753.3};
GN Name=COL4A3 {ECO:0000313|Ensembl:ENSOANP00000017753.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017753.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017753.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017753.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000017753.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017753.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR Ensembl; ENSOANT00000017756.3; ENSOANP00000017753.3; ENSOANG00000011207.3.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000161675; -.
DR HOGENOM; CLU_001074_2_3_1; -.
DR Proteomes; UP000002279; Chromosome 7.
DR Bgee; ENSOANG00000011207; Expressed in ovary and 4 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1077; COLLAGEN ALPHA-3(IV) CHAIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 20.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1612
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027728818"
FT DOMAIN 1387..1611
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 148..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1004
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1090
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1612 AA; 157617 MW; DBA814C5FA381695 CRC64;
MSGERRPSLW LWLLVFVSLG GWHRGDGTAA PASAPQGCVC KGKGRCYCDG TKGNKGEKGF
PGSPGAVGLE GFPGPEGLPG PQGPKGFPGL TGSAGPKGVR GMTGQPGFSG LPGLPGDPGN
VGPFGLPGLP GCNGTKGERG FTGYDGTPGY PGLPGPDGAK GEKGTPAHGE IGTSGRGDPG
VSGIRGFQGL PGPQGIPGPV GSQGPPGFLG FPGAIGPPGP KGHMGVKGIG EKGNPGVKGL
TGPPGQPGTV IVTLTGQDNT TDNKGDKGEK GARGPPGSPG PPGEPGDSYA SEKGAQGEPG
SEGKPGKDGV PGQPGFPGVK GEEGVTGLSG EAGLKGWKGD IGPAGFPGQT VYYDITQEKG
DEGLPGPKGL RGPRGPQGPE GHQGMGGRPG ASMPGARGRP GPPGTKGRKG ERGRPGRNEV
GIPGIPGNPG TPGFMGFPGP PGLPGKVTFQ TGPPGVRGWP GSLGDPGLPG AYGPKGEAGH
LCTQCICTPG APGVPGFPGS DGEAGVRGGQ GADGPKGSPG NPGIAGLPGF PGLPGSHGGQ
GLKGEKGEPS HLGLEGQVGS RGDPGIGGDP GRKGSDGIPG RPGIKGLPGP KGEPVLNGEK
GDRGFLGKPG KPGLPGPMGL AGPSTYGPQG EQGPKGAQGV PGFPGMPGNT GPKGEVSIAK
PIPGPPGLPG LPGLPGPPGP IGVVGSVGKC GDPGLPGPDG ESGSPGFVFP GPPGPKGDRG
KMGTKGLPGY PGEMGKPGTP GIPGFPGAKG DPGLAIPGTQ GKKGFPGESG NMGEYGGRGP
PGLPGPPGFP GHKGPIGPQG EPGLPGAPGD IGFPGECILC ATGFPGLPGL NGLKGQQGER
GLKGSKGDPG IPGLDRSGFP GDSGPPGIPG QQGKIGPPGS KGHSGRQGHL GAPGHKGEAG
LMGQPGLIGH PGFSGSPGLP GFRGDFGIPG LKGEKGCSGP RGEPGDKGNR GSSETSFFLG
DKGDQGPKGP PGDKGWKGDK GYPGPPGLKG LAGRPAPPGP PGVRGAPGVT GTPGAPGLVG
IPGRKGSMGM PGAKGERGTS GFPGPQGRPG LPGTTGMHGD KGEAGYGVGT QPGPEGPKGD
PGPPGPLGSK GVRGPPGLPG LLGPEGIDGN QGNYGDPGTP GEPGPDGDLG HKGSKGVPGY
PGKKGPQGMP GLPGPSGKMG EKGNQGRDGI PGPPGEKGEQ GLMGAPRGPN GIPGPKGNKG
DMGFPGSPGE PGLKGMMGNV GPEGPLGSKG PPGFPGFPGS LIPGQKGDQG PPGLRGRPGE
KGNQGLPGLF GPPGPIGLKG PPGPPGQPGA IKGLSLIGSP GPPGIPGAPG MQGDPGPPGA
VGEPGSRGPR GWPGYDGKPG TMGLDGEKGS KGIKGQTGLP GSVGYPGLKG KPGTSGPPVS
DSPPTRGFIF TRHSQSMEIP SCPGETMPLY SGYSLLFVQG NERAHGQDLG TLGSCLQRFS
TMPFLFCNNN EVCNFASRND YSYWLSTATL MPMDMAPITG RALESYISRC TVCEGSAMSI
AVHSQTTDVP SCPQGWISLW KGFSFVMYTS AGSEGSGQEL ASPGSCLEEF RPSPFIECHG
RGSCSYYSNS YSYWLASLNP GRMFRKPIPA TVKAGELEKI ISRCRVCMRS NL
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