ID F7FRV4_MONDO Unreviewed; 722 AA.
AC F7FRV4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DEAQ-box RNA dependent ATPase 1 {ECO:0000313|Ensembl:ENSMODP00000035137.2};
GN Name=DQX1 {ECO:0000313|Ensembl:ENSMODP00000035137.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000035137.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000035137.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000035137.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007496948.1; XM_007496886.2.
DR RefSeq; XP_007496949.1; XM_007496887.2.
DR AlphaFoldDB; F7FRV4; -.
DR STRING; 13616.ENSMODP00000035137; -.
DR Ensembl; ENSMODT00000036725.2; ENSMODP00000035137.2; ENSMODG00000004879.4.
DR GeneID; 100025915; -.
DR KEGG; mdo:100025915; -.
DR CTD; 165545; -.
DR eggNOG; KOG0925; Eukaryota.
DR GeneTree; ENSGT00940000159579; -.
DR HOGENOM; CLU_001832_5_7_1; -.
DR InParanoid; F7FRV4; -.
DR OMA; VLYHNFS; -.
DR OrthoDB; 5488182at2759; -.
DR TreeFam; TF105735; -.
DR Proteomes; UP000002280; Chromosome 5.
DR Bgee; ENSMODG00000004879; Expressed in placenta and 18 other cell types or tissues.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF108; ATP-DEPENDENT RNA HELICASE DQX1; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 33..236
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT DOMAIN 443..532
FT /note="Helicase-associated"
FT /evidence="ECO:0000259|SMART:SM00847"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 78825 MW; 1573DDB1E4D7D5CF CRC64;
MASDAPGPPE ESGPSSDGSD LAVNPYDGLP FSSRYYTLLA QRRALPVWAA RFSFLEQLES
SPSGVVLVSG EPGCGKSTQI PQWCAEFALA RGFQYGRVTV SQPQPLAALS LALRVADEMD
LSLGHEVGYS IPLEDCTGPD TLLRFCWDKL LLQEAASARG AGAWGVLVLD EAQERSVASD
VLQGLLRDAG LGNDLEGPRV VVVTDPAFES KLCAFWGNPP VIRVALGHEE GPIPVYKDPA
PTDVVGAACQ AVLELHQGGA PGDVLVYLPS EEDILRCCER LQKEAEHLGP QVTPFQVLPL
HPGLGRAVQA VYEDVEGGPR RIVVTHWLAN SSFSLPSIHH VVDSGLELRN VYNPQIRAES
QVMRPISKSQ AEARRLRTKG SPLGSCLRLY PKSFLELRTP LLPPPRICEE NLSRLVLLLK
RRDIAEPGEC HFLDRPAPEA LMQALEDLDY LAALDDDGDL SDLGVILSEL PLPPELAKAL
LAACEFDCVD EMLTLAAMLT TAPGFEGPPL CAEEAARRRA LEHPDGDHST LIQVYEAFIQ
SGEDENWCRA RGLSWAALCQ ARALRGELLE LMRRIELPLS PPAFGSEQNR KNLQRALVSG
YFLKVARDTD GAGNYLLLTH KHVAQLSPSC CYRSRRPPAQ PPPWVIYHNF SISQDNCLSI
VSEIEPHMLV ELAPSYFLSN LPPSESRDLL NQLREEMTGV PSGSEPPSQD LSLDDKDACA
LQ
//
