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Database: UniProt
Entry: F7G3D5_ORNAN
LinkDB: F7G3D5_ORNAN
Original site: F7G3D5_ORNAN 
ID   F7G3D5_ORNAN            Unreviewed;       779 AA.
AC   F7G3D5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 36.
DE   SubName: Full=Potassium voltage-gated channel subfamily Q member 3 {ECO:0000313|Ensembl:ENSOANP00000012876};
GN   Name=KCNQ3 {ECO:0000313|Ensembl:ENSOANP00000012876};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000012876, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000012876}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012876};
RX   PubMed=8919867; DOI=10.1007/BF02198841;
RA   Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
RT   "The mitochondrial genome of a monotreme--the platypus
RT   (Ornithorhynchus anatinus).";
RL   J. Mol. Evol. 42:153-159(1996).
RN   [2] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [3] {ECO:0000313|Ensembl:ENSOANP00000012876}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012876};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000012876}.
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DR   EMBL; AAPN01092548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01092549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01092550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01092551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAPN01092552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F7G3D5; -.
DR   STRING; 9258.ENSOANP00000012876; -.
DR   Ensembl; ENSOANT00000012878; ENSOANP00000012876; ENSOANG00000008100.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   InParanoid; F7G3D5; -.
DR   OMA; RNEPYVA; -.
DR   OrthoDB; EOG091G02ZT; -.
DR   TreeFam; TF315186; -.
DR   Proteomes; UP000002279; Chromosome 4.
DR   Bgee; ENSOANG00000008100; -.
DR   GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033268; C:node of Ranvier; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR020969; Ankyrin-G_BS.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR003948; K_chnl_volt-dep_KCNQ3.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF174; PTHR11537:SF174; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01462; KCNQ3CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM     34     52       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     64     84       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    105    122       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    168    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    238    264       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    260       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      345    547       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   779 AA;  88118 MW;  8DBD36E18EABDC92 CRC64;
     SRPLQCQDTW HRIIQGLVYI AWERLDGATD LSKASLFLIV LGCLILAVLT TFKEYETVSG
     DWLLLLETFA IFVFGAEFAL RIWAAGCCCR YKGWRGRLKF ARKPLCMLDI FVLIASVPVV
     AVGNQGNVLA TSLRSLRFLQ ILRMLRMDRR GGTWKLLGSA ICAHSKELIT AWYIGFLTLI
     LSSFLVYLVE KDVPETDADG FEAKEEFETY ADALWWGLIT LATIGYGDKT PKTWEGRLIA
     ATFSLIGISF FSLPAGILGS GLALKVQEQH RQKHFEKRRK PAAELIQAAW RYYATNPNRL
     DLVATWRFYE SIVSFPYFSQ KLGLLDRVRL SNPRGSNTKG KLFTPLNVDA IEESPSKEPK
     NVGLNNKERF RTAFRMKAYA FWQSSEDAGT GDPLTEERGY SNEFLIEDMI PTLKSAIRAV
     RILQFRLYKK KFKETLRPYD VKDVIEQYSA GHLDMLSRIK YLQTRVDMIF TPGPPSTPKH
     KKFQKGGAFS YPPQQSPRND PYVAKATASE TEDQSMMGKF VKVERQVHDM GKKLDFLVDM
     HMQHTEQLQV QVTDFFPSRE TVFPAEVAKK EEENRYSELK SIMNYSGPCT HDTPFNCHQV
     PINKVRPYGF FAHDPVTFSH DPVTLSLSGR RSGKLQTAPS SAAYAERPTV LPILTLLDSR
     AGYPSQPELP SAYSDRISPR QRRRQRPSLT RDSDTPLSLL SVNHEELARS PSGFSISQER
     DDYLFGPSGG SSWMREKRYL AEGETDTDTD PFTPSGSMPL SSTGDGVSDS VWTPSSKPI
//
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