ID F7GFM5_MACMU Unreviewed; 491 AA.
AC F7GFM5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Keratin 39 {ECO:0000313|Ensembl:ENSMMUP00000002008.1};
GN Name=KRT39 {ECO:0000313|Ensembl:ENSMMUP00000002008.1,
GN ECO:0000313|VGNC:VGNC:74176};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002008.1, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002008.1}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002008.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_001102045.1; XM_001102045.2.
DR AlphaFoldDB; F7GFM5; -.
DR SMR; F7GFM5; -.
DR STRING; 9544.ENSMMUP00000002008; -.
DR PaxDb; 9544-ENSMMUP00000002008; -.
DR Ensembl; ENSMMUT00000002125.3; ENSMMUP00000002008.1; ENSMMUG00000001510.3.
DR GeneID; 702838; -.
DR KEGG; mcc:702838; -.
DR CTD; 390792; -.
DR VEuPathDB; HostDB:ENSMMUG00000001510; -.
DR VGNC; VGNC:74176; KRT39.
DR eggNOG; ENOG502SH7Y; Eukaryota.
DR GeneTree; ENSGT00940000162203; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; F7GFM5; -.
DR OMA; PCATKCE; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000006718; Chromosome 16.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF106; KERATIN, TYPE I CYTOSKELETAL 39; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 96..407
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 93..170
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 206..244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 351..392
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 491 AA; 55744 MW; DB6B5AFDB35E7361 CRC64;
MDTKGCTTTN SPSTPSQNCS RITNVSTISS NNCCHSGGLK VKNCQPAGHT LRTTRDQGCQ
PTPCFCRKPI YLINNFILHS SLDDCSWYGE GINSNEKETM QILNERLANY LEKVRMLERE
NAELESKIQE ENNKELPVLC PDYLSYYTTI EELQQKILCT KAENSRLVSQ IDNTKLTADD
LRAKYEAEVS LRQLVEADAN GLKQILNVLT LGKADLEAQV QSLKEELLCL KNNHKEEINS
LQCQLGERLH IEVTAAPSVD LNQVLQEMRC QYESIMETNR KDVEQWFNTQ IEELNQQVVT
SSQQQQCCQK EIIELRRTVN TLEVELQAQH RMRDSQECIL TETEARYTAL LTQIQSLIDN
LEAQLAEIRC ALERQNQEYE ILLDVKSRLE CEITTYRSLL ESLDGKRPCY PCTTKCEPSP
WTSYKSGAME CTAPACTSSA PCGLKEHCSA YGPLSRILVK ICTITKEIKD GKVISSYEHV
QPCFIIRPAK V
//
