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Database: UniProt
Entry: F7GLF3_CALJA
LinkDB: F7GLF3_CALJA
Original site: F7GLF3_CALJA 
ID   F7GLF3_CALJA            Unreviewed;      1910 AA.
AC   F7GLF3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   07-JUN-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSCJAP00000011922};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011922, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000011922, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000011922}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000011922}.
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DR   EMBL; ACFV01062110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000011922; -.
DR   Ensembl; ENSCJAT00000012574; ENSCJAP00000011922; ENSCJAG00000006448.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7GLF3; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000008225; Chromosome 6.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    114    134       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    146    165       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    237    259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    380    403       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    699    722       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    734    755       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    767    787       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    828    847       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    906    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1232   1251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1257   1275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1317   1339       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1425   1451       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1529       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1541   1559       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1566   1586       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1598   1618       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1630   1658       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1734   1760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      118    414       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      704    926       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      942   1185       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1192   1456       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1510   1758       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1910 AA;  219895 MW;  3A2ED0BCEB2E0348 CRC64;
     MLASLEPKGL VPFTRESFER IQQRIAKTHN EEHEEEDLKP NTDLEVGKEL PFTYGNLSRG
     MVSEPLEDVD PYYHEKKNTF IVLNKNRTIF RFNAASILCT LSPFNCIRGT TIKVLIATLF
     RLFILISVLT DCIFMSLTNL PKWRPVVENT LLGIYTFEIL VKLFARGVWA GSFSFLGDPW
     NWLDFSVTVF EIIIRYSPLS FIPMLQTVRT LQEVKLIQVL SSLKSLVGVL ICCVKKLTGV
     IILTLFFLSI FSLIGMGLFM GNLKHKCFRW PQENENETLH NRTGNPYYIR GKNHLALYIK
     ETENFYYLEG ERYALLCGNR TDAGQCPEGY VCVKAGINPD QGFTNFDSFG WALLALFRLM
     TQDYPEALYH QILYASGKVY MIFFVVVSFW FSFYMASLFL GILAMAHEEE KQRVGETTKN
     TEPKFQKTGK ELQGGNETVP FLSDGGVLYF SMLLLELSPI EPENKKERAA MTRTLSYKQD
     KKREKLMPKS PTMSKRKVVG HISFQSGKCR TSHNIKFSAE TVSFYWSHGL QVKLSYDCQL
     LAAPQSDIHR TTLLPPTLCP ILHIPQQNWP TRMSGWVIGK PQQLTPSVLG SGRPYVSNPK
     AKAIQIEMKK RSPASTDTSL DVLEDATLRH KYAICFIFFR LTQPNMNTIE GIFNFYSFFS
     ELEKSKKICP LCWYKFAETF LIWNCSPCWL KLKEFVHRII TAPFTDLFLF ICIILNVSFL
     ALEHYPMSEQ TSNLLSTGNL VFIGIFTAEM ILKIIAMHPY GYFQVGWNIF DSIIVFLGLA
     ELFLAYIEGL AVFQSFRMLR IFKLGKYWPT FQILMWSLSN SWVALKDLVL LLFTFIFFSA
     AFGMRLFGQN YEKFVCHIDR DCQLPRWHMH DFFHSFLNVF RIICGEWIET LWDCMQVAGQ
     SWCISFYLMV ILIGNLLVLY LFLALVSLFS SCKDVTAEEN DEAKNLRLAM AKIKKEINYA
     FLKILCKKQN IPEETMDRVN EVYVKEDISD HTLSELSNTQ DFLKDKEKSS GTEKNMTENE
     SQSLIPSPSV SETVPIASGE SDIENLDNKE IQNHLRALED QGMFLQVPII SGTIMFPRPL
     LFWQMLSART SQIDCLIGVQ FQLFKVLPSP TKAIFILKIK QSSSSECSTV DIAISEEEEM
     VYGHESSKHP KNECYIQKKV TGCSMITVVT TPWKGKICRN IRKTCCKIVE NNWFKCFIGL
     VTLLSTSTLA LEDIYIDQRK TVKILLEYAD MIFTYIFILE MLLKWMAYGF KAYFSNSWYR
     LDFMVVIVFC LSLIGKTREE LQPLISIKFL RPLRVLSQFE RMKVVVRALI KTTLPTLNVF
     LVCLMIWLTF SIMGIHLFAG TFYECIDPTS GERFPSSEVM NKGQCESLLF NDSMPWENAK
     LNFDNVGNGF LSLLQLATFN GWITIMNSAI DSVAINMQPR FEDNIYMYCY FINFIILGVF
     LPLSMLISAI VDNFNKHKIK YLGGSNIFIT VKQRKQYSRL KKLMYEDSQR PIPHPRSKLQ
     GFIFDLVTSQ VFNVIVMVLI CFQAIAMMID TDEHSLQMEI ALYWINLIFV ILYTMECILK
     LIAFRCFYFT IAWNIFDFMV VIFSITGKIL NNIIQKSYYL VPPSLVKLIL LSRIIHILRL
     GKGPKVFHNL MLPLMLSLPA LLNLILLIFL VMFIYAIFGM YNFAYVKKEA GINDVSNFET
     FGSSMLCLFQ VAIFAGWDGM LVAIFNSKWS DCDPDKINPG TQVRGDCGNP SVGILYFVSY
     ILISWVIIVN MYIVVVMEFL TIASKKKNRT LSEDDFRKFF QVWKRFDPDR TQYIDSSKLS
     DFAAALDPPL FMAKPNKGQL IALDLPMAVG DRIHCLDILL AFTKRVMGQD VRMEKVLSEI
     ESGFLLANPF KITCEPITTT LKRKQEAVSA TIIQRAYKNY RLRQKDKNTS
//
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