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Database: UniProt
Entry: F7GVT5_CALJA
LinkDB: F7GVT5_CALJA
Original site: F7GVT5_CALJA 
ID   F7GVT5_CALJA            Unreviewed;      1998 AA.
AC   F7GVT5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUL-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSCJAP00000018440};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018440, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000018440, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000018440}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000018440}.
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DR   EMBL; ACFV01126119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01126128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000019483; ENSCJAP00000018440; ENSCJAG00000009878.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000008225; Chromosome 17.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    861       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    881    902       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    914    939       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1245   1261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1273   1294       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1322   1348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1426   1452       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1511   1529       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1541   1559       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1571   1591       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1628   1656       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1731   1754       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      478    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    943       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      953   1200       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1204   1461       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1510   1764       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1998 AA;  225038 MW;  DE67EC4806D792AE CRC64;
     MANLLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESREGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYILSPFHPI
     RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGSV
     WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
     AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT IHERRSKRRK
     RMSSGTEECG EDRLPKSDSE DGPRAVNRLS LTHGLSRTSM KPRSSRGSIF TFRRRDLGSE
     TDFADDENST AGESESHHTS LLVPWPLRRT GAQGQPNIGT AAPGHALNGK KNSTVDCNGV
     VSLVGAGDPE ATSPGSHLLR PVMLEHPLDT TTPSEEPGGP RMLTPQAPCV DGFEEPEARQ
     RALSAVSVLT SALEELEESQ RKCPPCWNRF AQRFLIWECC PLWISVKQGV KFVVTDPFAD
     LTITMCIVLN TLFMALEHYN MTSEFEDMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG
     WNIFDSIIVV LSLMELGLSR MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKNYSELRH SDSGLLPRWH MMDFFHAFLI IFRILCGEWI
     ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP DEDRELNNLQ
     LALARIQRGL RFIKWTTWDF CCGLLRQRPQ KPAALAAPGQ LPSCIATPHS PPPPETEKAP
     PARKETRFEE GEQLGQGTPG DPETVCVPIA VAESDTDDQE EDEENSLGPE EESCKQQESQ
     PVSDGPEAPP DSRTWSQVSA TTSSEAEASA SQADWQQQRK VEPRAPGCSE TPEDSYSEGS
     TADMTNTAEL LEQIPDLGQD VKDPEDCFTE GCVRRCPCCA VDTTQAPGKV WWQLRKTCYR
     IVEHSWFETF IIFMILLSSG ALAFEDIYLE ERKTIKVLLE YADKMFTYVF VLEMLLKWVA
     YGFKKYFTNA WCWLDFLIVD VSLVSLVANT LGFAEMGPIK SLRTLRALRP LRALSRFEGM
     RVVVNALVGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GRCINQTEGD LPLNYTIVNN
     KSQCESLNMT GELYWTKVKV NFDNVGAGYL ALLQVYEEQP QWEYNLYMYI YFVVFIIFGS
     FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPLNKYQ
     GFIFDVVTKQ AFDVTIMFLI CLNMVTMMVE TDDQSPEKVN ILTKINLLFV AIFTGECIFK
     MAALRHYYFT NSWNIFDFVV VILSIVGTVL SDIIQKYFFS PTLFRVIRLA RIGRILRLIR
     GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMAN FAYVKWEAGI DDMFNFQTFA
     NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS RGDCGSPAVG ILFFTTYIII
     SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYETW EKFDPEATQF IEYSALSDFA
     DALSEPLRIA KPNQISLINM DLPMVSGDRI HCMDILFAFT KRVLGESGEM DALKIQMEEK
     FMAANPSKIS YEPITTTLRR KHEEVSATVI QRAFRRHLLQ RSMKHASFLF RQQAGSGLSE
     EDAPEREGLI AYMMNENFSR PPGLPSSSSI SSTSFPPSYD SVTRATSDNL QVRGSDDSHS
     EDLADFPPSL DRDRESIV
//
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