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Database: UniProt
Entry: F7GX43_MACMU
LinkDB: F7GX43_MACMU
Original site: F7GX43_MACMU 
ID   F7GX43_MACMU            Unreviewed;       584 AA.
AC   F7GX43;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 54.
DE   SubName: Full=Eukaryotic translation initiation factor 2D {ECO:0000313|Ensembl:ENSMMUP00000003400};
DE   SubName: Full=Eukaryotic translation initiation factor 2D isoform 1 {ECO:0000313|EMBL:AFE66486.1};
GN   Name=EIF2D {ECO:0000313|EMBL:AFH30577.1,
GN   ECO:0000313|Ensembl:ENSMMUP00000003400};
GN   Synonyms=LGTN {ECO:0000313|EMBL:AFE66486.1};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003400, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000003400, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003400,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000003400}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003400};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:AFE66486.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Caudate {ECO:0000313|EMBL:AFE66486.1}, Testis
RC   {ECO:0000313|EMBL:AFI34253.1}, and Thymus
RC   {ECO:0000313|EMBL:AFH30577.1};
RX   PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA   Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
RA   Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
RA   Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
RA   Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
RT   "A new rhesus macaque assembly and annotation for next-generation
RT   sequencing analyses.";
RL   Biol. Direct 9:20-20(2014).
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DR   EMBL; JSUE03002952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03002953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JU322730; AFE66486.1; -; mRNA.
DR   EMBL; JU473773; AFH30577.1; -; mRNA.
DR   EMBL; JV044182; AFI34253.1; -; mRNA.
DR   RefSeq; NP_001253699.1; NM_001266770.1.
DR   UniGene; Mmu.4725; -.
DR   STRING; 9544.ENSMMUP00000003400; -.
DR   Ensembl; ENSMMUT00000003596; ENSMMUP00000003400; ENSMMUG00000002528.
DR   GeneID; 695274; -.
DR   KEGG; mcc:695274; -.
DR   CTD; 1939; -.
DR   eggNOG; KOG2522; Eukaryota.
DR   eggNOG; ENOG410XSAV; LUCA.
DR   GeneTree; ENSGT00550000074865; -.
DR   KO; K15027; -.
DR   OMA; REQPYHP; -.
DR   OrthoDB; EOG091G0DTH; -.
DR   TreeFam; TF105830; -.
DR   Proteomes; UP000006718; Chromosome 1.
DR   Bgee; ENSMMUG00000002528; -.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0002192; P:IRES-dependent translational initiation of linear mRNA; IBA:GO_Central.
DR   GO; GO:0075522; P:IRES-dependent viral translational initiation; IEA:Ensembl.
DR   GO; GO:0032790; P:ribosome disassembly; IEA:Ensembl.
DR   Gene3D; 1.10.245.10; -; 1.
DR   Gene3D; 2.30.130.10; -; 1.
DR   Gene3D; 3.30.780.10; -; 1.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR003121; SWIB_MDM2_domain.
DR   Pfam; PF01253; SUI1; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF47592; SSF47592; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS50890; PUA; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Initiation factor {ECO:0000313|EMBL:AFE66486.1};
KW   Protein biosynthesis {ECO:0000313|EMBL:AFE66486.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT   DOMAIN       93    173       PUA. {ECO:0000259|PROSITE:PS50890}.
FT   DOMAIN      491    564       SUI1. {ECO:0000259|PROSITE:PS50296}.
SQ   SEQUENCE   584 AA;  64499 MW;  8BE2DAFE7FCF4CEF CRC64;
     MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI VKLYAYKGDA
     VTVYVSGGNP ILFELEKNLY PTVYTLWSYP DLLPTFTTWP LVLEKLVGGA DLMLPGLVMP
     PAGLPQVQKG DLCAISLVGN RAPVAIGVAA MSTAEMLTSG LKGRGFSVLH TYQDHLWRSG
     NKSSPPSIAP LALDSADLSE EKGSVQVDST LQGDMRHMIL EGEEENGEAH QACEEKSLSE
     APEDTSTGGL NQDSTDSKTL QEQMDELLQQ CFLHALKCRV KKADLPLLTS TFLGSHMFSC
     CPEGRQLDIK KSSYKKLSKF LQQMQQEQII QVKELSKGVE SIVAVDWKHP RITSFVIPEP
     SPTSQTIQEG SREQPYHPPD IKPLYCVPAS MTLLFQESGH KKGSFLEGSE VRTIIINYAK
     KNDLVDADNK NLVKLDPILC DCILEKNEQH TVMKLPWDSL LTRCLEKLQP AYQVTFPGQE
     PIVKKGKICP IDITLAQRAS NKKVTVVRNL EAYGLDPYSV AAILQQRCQA STTVTSAPGA
     KDSLQVQIQG NQVHHLGWLL LEEYQLPRKH IQGLEKAPKP GKKK
//
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