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Database: UniProt
Entry: F7GYI5_MACMU
LinkDB: F7GYI5_MACMU
Original site: F7GYI5_MACMU 
ID   F7GYI5_MACMU            Unreviewed;      2368 AA.
AC   F7GYI5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   27-SEP-2017, entry version 37.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSMMUP00000022708};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000022708, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000022708, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000022708,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000022708}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000022708};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000022708}.
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DR   EMBL; JSUE03016633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03016634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000024264; ENSMMUP00000022708; ENSMMUG00000017256.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000006718; Chromosome 16.
DR   Bgee; ENSMMUG00000017256; -.
DR   ExpressionAtlas; F7GYI5; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF256; PTHR10037:SF256; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    121    140       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    212    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    340    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    367    392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    742    760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    772    793       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    863    882       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    939    962       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1286   1304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1324   1345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1357   1376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1421   1443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1523   1546       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1610   1631       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1643   1666       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1744   1763       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1827   1849       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      741    967       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1284   1556       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1609   1859       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1555   1589       {ECO:0000256|SAM:Coils}.
FT   COILED     1848   1872       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2368 AA;  261821 MW;  08EC61E34AF74DFE CRC64;
     MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RRGPGSAEKD PGSADSEAEG LPYPALAPVV
     FFYLSQDSRP RSWCLRTVCN PYPSGMLVIL LNCVTLGMFR PCEDIACDSQ RCRILQAFDD
     FIFAFFAVEM VVKMVALGIF GKKCYLGDTW NRLDFFIVIA GMLEYSLDLQ NVSFSAVRTV
     RVLRPLRAIN RVPSMRILVT LLLDTLPMLG NVLLLCFFVF FIFGIVGVQL WAGLLRNRCF
     LPENFSLPLS VDLERYYQTE NEDESPFICS QPRENGMRSC RSVPTLRGEG GGGPPCGLDY
     EAYNSSSNTT CVNWNQYYTN CSAGEHNPFK GAINFDNIGY AWIAIFQVIT LEGWVDIMYF
     VMDAHSFYNF IYFILLIIVG SFFMINLCLV VIATQFSETK QRESQLMREQ RVRFLSNAST
     LASFSEPGSC YEELLKYLVY ILRKAARRLA QVSRAAGVRA GLLSSPAPLG GQETQPSSSC
     SRSHRRLSVH HLVHHHHHHH HHYHLGNGTL RVPRASPEIQ DRDANGSRRL MLPPPSTPAV
     SGGPPGGAES VHSFYHADCH LEPVRCQAPP PRSPSEASGR TVGSGKVYPT VHTSPPPETL
     KEKALVEVAA SSGPATLTSL NIPPGPYSSM HKLLETQSTG ACQSSCKISS PCLKADSGAS
     GPDSCPYCAR AGAGEVELAD REMPDSDSEA VYEFTQDAQH SDLRDPHSRR QRSLGPDAEP
     SSVLAFWRLI CDTFRKIVDS KYFGRGIMIA ILVNTLSMGI EYHEQPEELT NALEISNIVF
     TSLFALEMLL KLLVYGPFGY IKNPYNIFDG VIVVISVWEI VGQQGGGLSV LRTFRLMRVL
     KLVRFLPALQ RQLVVLMKTM DNVATFCMLL MLFIFIFSIL GMHLFGCKFA SERDGDTLPD
     RKNFDSLLWA IVTVFQILTQ EDWNKVLYNG MASTSSWAAL YFIALMTFGN YVLFNLLVAI
     LVEGFQAEEI SKREDASGQL SCIQLPVDSQ GGDANKSESE PDFFSPSLDG DGDRKKCLAL
     VSLGEHPELR KSLLPPLIIH TAATPMSLPK STSTGLGEAL GPMSRRTSSS GSAEPGAAHE
     MKSPVGDHSS PAHPQPSARS SPHSPWSAAS SWTSRRSSRN SLGRAPSLKR RSPSGERRSL
     LSGEGQESQD EEESSEEERA SPAGSDCRHR ESLEREAKSS FDLPDTLQVP GLHRTASGRG
     SASEHQDCNG KSASGRLARA LRPDDPPLDG DDADDEGNLS KGERVRAWIR ARLPACCLER
     DSWSAYIFPP QSRFRLLCHR IITHKMFDHV VLVIIFLNCI TIAMERPKID PHSAERIFLT
     LSNYIFTAVF LAEMTVKVVA LGWCFGEQAY LRSSWNVLDG LLVLISVIDI LVSMVSDSGT
     KILGMLRVLR LLRTLRPLRV ISRAQGLKLV VETLMSSLKP IGNIVVICCA FFIIFGILGV
     QLFKGKFFVC QGEDTRNITN KSDCAEASYR WVRHKYNFDN LGQALMSLFV LASKDGWVDI
     MYDGLDAVGV DQQPIMNHNP WMLLYFISFL LIVAFFVLNM FVGVVVENFH KCRQHQEEEE
     ARRREEKRLR RLEKKRRSKE KQMAEAQCKP YYSDYSRFRL LVHHLCTSHY LDLFITGVIG
     LNVVTMAMEH YQQPQILDEA LKICNYIFTV IFVLESVFKL VAFGFRRFFQ DRWNQLDLAI
     VLLSIMGITL EEIEVNASLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL LDTVMQALPQ
     VGNLGLLFML LFFIFAALGV ELFGDLECDE THPCEGLGRH ATFRNFGMAF LTLFRVSTGD
     NWNGIMKDTL RDCDQESTCY NTVISPIYFV SFVLTAQFVL VNVVIAVLMK HLEESNKEAK
     EEAELEAELE LEMKTLSPQP HSPLGSPFLW PGVEGPDSPD SPKPGALHPA AHARSASHFS
     LEHPTDGQLF DTISLLIQGS LEWELKLMDE LAGPGGQPSA FPSAPSLGGS DPQIPLAEME
     ALSLTSEIVS EPSCSLALTD DSLPDDMHTL LLSAPESNVQ PHPTELPGPD LLTVRKSGVS
     RTHSLPNDSY MCRHGSIAEG PLGQRGWGLP KAQSGSVLSV HSQPADTSYI LQLPKDAPHL
     LQPYSTPTWG TIPKLPPPGR SPLAQRPLRR QAAIRTDSLD VQGLGSREDL LAEVSGPSLP
     LARAYSFWGQ SSTQAQQHSR SHSNISKHMP PRAPCPGPQP NWDKGPPETR SSLELDTELS
     WISGDLLPPG GQEEPPSPRD LKKCYSVEAQ SCQRRPTSWL DEQRRHSIAV SCLDSGSQPH
     LGTDPSNLGG HRPKKKLSPP SISIDPPESQ GPRPPPSPGV CLRRRAPSSD SKDPLASGPP
     DSMAASPSPK KDVLSLSGLS SDPADLDP
//
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