ID F7GYN2_MACMU Unreviewed; 950 AA.
AC F7GYN2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Leucine rich repeat and coiled-coil centrosomal protein 1 {ECO:0000313|Ensembl:ENSMMUP00000008406.3};
GN Name=LRRCC1 {ECO:0000313|Ensembl:ENSMMUP00000008406.3,
GN ECO:0000313|VGNC:VGNC:84012};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000008406.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000008406.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008406.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7GYN2; -.
DR SMR; F7GYN2; -.
DR Ensembl; ENSMMUT00000008940.3; ENSMMUP00000008406.3; ENSMMUG00000006370.4.
DR VEuPathDB; HostDB:ENSMMUG00000006370; -.
DR VGNC; VGNC:84012; LRRCC1.
DR GeneTree; ENSGT00940000157414; -.
DR HOGENOM; CLU_011297_1_0_1; -.
DR TreeFam; TF329470; -.
DR Proteomes; UP000006718; Chromosome 8.
DR Bgee; ENSMMUG00000006370; Expressed in spermatid and 22 other cell types or tissues.
DR ExpressionAtlas; F7GYN2; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF13; LEUCINE RICH REPEAT AND COILED-COIL CENTROSOMAL PROTEIN 1; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00365; LRR_SD22; 2.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT REGION 313..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 484..640
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 782..943
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 315..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 110119 MW; 81444E3A4071BD8D CRC64;
MEAAAAAAEA EVENEDGDSS CGDVCFMDKG LQSISELSLD STLHAINLHC NNISKIEAID
HIWNLRHLDL SSNQISRIEG LNTLTKLCTL NLSCNLITKV EGLEELINLT RLNLSYNHIN
DLSGLIPLHG IKHKLRYIDL HSNCIDSIHH LLQCTIGLHF LTNLILEKDG NDNPVCRLPG
YRAVILQTLP QLRILDCKNI FGEPVNLAEI NSSQLQCLEG LLDNLVSSDS PLNISEDEII
DRMPVITAPI DELVPLEQFA SPPSDAVLTS FMSVCQSSEP EKSNHESDLQ NEIKLQKLDD
QILQLLNETC NSIDNVPEKD PRPKRDTDIT SESDYGNRKE CNKKVPRRSK IPYYAKTIQT
IKHHNKNCNS FVSCNRKMKP PYLKELYVSS SLANCPMLQE SEKPKTEIIK VDKSHSEDNT
YQSLVEQLDQ EREKRWRAEQ AENKLMDYID ELHKHANEKD DIHSLALLTT DRLKEIIFRE
RNSKGQLEVM VHKLQNEIKK LTVELMKAKD QQEDHLKHLR TLEKSLEKME RQKRQQQAAQ
IRLIQEVELK ASAADREIYL LRTSLHRERE QVQQLHELLA LKEQEHRKEL ETREFFTDTE
FQDALAKEIA KEEKKHEQVI KEYQEKIDML SQQYMDLENE FRIALTVEAR RFQDVKDGFE
NVATELAKSK HALIWAQRKE NESSSLIKDL TCMVKEQKTK LAEVSKLKQE TAANLQNQIN
TLEILIEDDK QKSIQIELLK HEKVQLISEL AAKESLIFGL RTERKVWGHE LAQQGSSLAQ
NRGKLEAQIE SLSRENECLR KTNESDSDAL KIKCKIIDDQ TETIRKLKDC LQEKDEHIKR
LQEKITEIEK CTQEQLDEKS SQLDEILEKL ERHNERKEKL KQQLKGKEVE LEEIRKAYST
LNRKWHDKGE LLCHLETQVK EVKEKFENKE KKLKAERDKS IELQNWNLQN
//
