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Database: UniProt
Entry: F7H1J0_CALJA
LinkDB: F7H1J0_CALJA
Original site: F7H1J0_CALJA 
ID   F7H1J0_CALJA            Unreviewed;       873 AA.
AC   F7H1J0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   Name=GBA2 {ECO:0000313|Ensembl:ENSCJAP00000018203};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018203, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000018203, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000018203}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Golgi apparatus membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Note=Not localized to lipid
CC       rafts. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000018203}.
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DR   EMBL; ACFV01033859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01033860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01033861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000019234; ENSCJAP00000018203; ENSCJAG00000009895.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   GeneTree; ENSGT00390000010998; -.
DR   Proteomes; UP000008225; Chromosome 1.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR028944};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Golgi apparatus {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN       98    402       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      468    833       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   873 AA;  99100 MW;  D3D3A2D3D5962001 CRC64;
     XKETRCCNPE DSGQLMASYE GKAMGYQVPP FGWRICLAHE FTEKRKPFQA NNVSLSNMIK
     HIGMGLRYLQ WWYRKTQVEK KTPFIDMINS VPLRQIYGCP LGGIGGGTIT RGWRGQFCRW
     QLNPGMYRHQ TVIADQFTVC LRREGQTVYQ QVLSLERPSV LRSWNWGLCG YFAFYHALYP
     RAWTVYQLPG QNVTLTCRQI TPILPHDYQD SSLPVGVFVW DVENEGDEDL DVSIMFSMRN
     GLGGGDDAPG GLWNEPFHLE RDGKTVQGLL LHHPTLPNPY TMAVAARVTA DTTVTHITAF
     DPDGTGQQVW QDLLQDGQLD SPAGQSTPTQ KGVGVAGAVC VSSKLRPRGQ CRLEFSLAWD
     MPRIMFGAKG QVHYRRYTRF FGQDGDAAPA LSHYALCQYT EWEERISAWQ NPVLDDRLLP
     AWYKSALFNE LYFLADGGTV WLEVREDSLP QELDGNMCHL RPTLRDYGRF GYLEGQEYRM
     YNTYDVHFYA SFALIMLWPK LELSLQYDMA LATLREDLTR RRYLMSGVMA PVKRRNVIPH
     DIGDPDDEPW LRVNAYLIHD TADWKDLNLK FVLQVYRDYY LTGDQNFLKD MWPVCLAVME
     SEMKFDKDHD GLIENGGYAD QTYDGWVTTG PSAYCGGLWL AAVAVMVQMA AVCGAQDIQD
     KFSSILSRGQ EAYERLLWNG RYYNYDSSSQ PQSRSVMSDQ CAGQWFLKAC GLGEGDTEVF
     PTPHVVRALQ TIFELNVQAF AGGAMGAVNG MQPHGVPDKS SVQSDEVWVG VVYGLAATMI
     QEGLTWEGFQ TAEGCYRTVW ERLGLAFQTP EAYCQQRVFR SLAYMRPLSI WAMQLALQQQ
     QHKKASRPKV KQDTGLRTGP MFGPKEAMNL SPE
//
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