ID F7H346_CALJA Unreviewed; 1720 AA.
AC F7H346;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN Name=POLR1A {ECO:0000313|Ensembl:ENSCJAP00000036331.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000036331.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000036331.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000036331.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
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DR RefSeq; XP_002757589.1; XM_002757543.3.
DR STRING; 9483.ENSCJAP00000036331; -.
DR Ensembl; ENSCJAT00000038370.5; ENSCJAP00000036331.4; ENSCJAG00000019547.5.
DR GeneID; 100408689; -.
DR KEGG; cjc:100408689; -.
DR CTD; 25885; -.
DR eggNOG; KOG0262; Eukaryota.
DR GeneTree; ENSGT00920000149138; -.
DR HOGENOM; CLU_000487_2_4_1; -.
DR InParanoid; F7H346; -.
DR TreeFam; TF103033; -.
DR Proteomes; UP000008225; Chromosome 14.
DR Bgee; ENSCJAG00000019547; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 2.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 295..642
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1365..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1409
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1448
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1720 AA; 194379 MW; DB5691A8FC519FE1 CRC64;
MLISKNMPWR RLQGISFGMY SAEELKKLSV KSITNPRFLD SLGNPSANGL YDLALGPADS
KEVCSTCAQD FNNCSGHLGH IELPLMVYNP LLFDKLYLLL RGSCLNCHML TCPRAVIHLL
LCQLRVLEVG ALQAVYELER ILNRFLEENA DPSASEIQEE LEQYTTEIVQ NNLLGSQGSH
VKNVCESRSK IIAFFWKTHM NPKRCPHCKT GRSVVRKEHN SKLTITFPAT VHRTAGQKDS
EPLGIEEAQM GKRGYLTPTS AREHLFALWK NEGFFLNYLF SGVDNDGMES RFNPSVFFLD
FLVVPPSRYR PVSRLGDQMF TNGQTVNLQA VMKDVVLIRK LLALMAQEQK LPGDVAVPLT
DEGKDSLITI DRAFLSTIPG QSFIDKLYNI WIRLQSHVNI VFDSEMDKLM TDKYPGIRQI
LEKKEGLFRK HMMGKRVDYA ARSVICPDMY INTNEIGIPM VFATKLTYPQ PVTPWNVQEL
RQAVINGPNV HPGASMVINE DGSRTALSAV DVSQREAVAK QLLTPAMGAP KPQGTKIVCR
HVKNGDILLL NRQPTLHRPS IQAHHARILP EEKVLRLHYA NCKAYNADFD GDEMNAHFPQ
SELGRAEAYV LACTDQQYLV PKDGQPLAGL IQDHMVSGAS MTTRGCFFTR EQYMELVYRG
LTDKLGRVKL FPPSILKPFP LWTGKQVVST LLINIIPEDH IPLNLTGKAK ITGKAWVKET
PQSVPGFNPD SMCESQVIIR EGELLCGVLD KAHYGSSAYG LVHCCYEIYG GEISGKVLTC
LARLFTAYLQ LYRGFTLGVE DILVKLKADV KRQQIIEESI HCGLRAVRAA LNLPEAASYD
EVREKWQDAH LGKDQRDFNM IDLKFKEEVN HYSNEINKAC MPFGLHRQFP ENSLQMMVQS
GAKGSTVNTM QISCLLGQIE LEGRRPPLMA SGKSLPCFEP YEFTPRAGGF VTGRFLTGIK
PPEFFFHCMA GREGLVDTAV KTSRSGYLQR CIIKHLEGLV VQYDLTVRDS DGSVVQFLYG
EDGLDVPKTQ FLQPKQFPFL ASNYKAIMKS NHLHEVLSRA DPKKALRHFR AIKKWQSKHP
NTLLRRGAFL NYSQKIQTAV KALNLESGNR NGRSLGTQEM LRMWYELDEH SRRKYQKKAA
SCPDPSLSVW RPDIHFASVS ETFETKVDDY SQEWAAQTER SYEKSELSLD RLRTLLQLKW
QRSLCEPGEA VGLLAAQSIG EPSTQMTLNT FHFAGRGEMN VTLGIPRLRE ILMVASANIK
TPMMSVPVLN TKKALKRVKS LKKQLTRVCL GEVLQKIDVQ ESLCIEEKQN KFRVYQLRFQ
FLPHACYQQE KCLRPEDILH FMETRFFKLL MESIRKKNNK ASAFRNVNTR RATQRDLDNA
EESGRSRGEQ EGDEEEEGHI VDAEADEGDT DASDAKRKEK QEEEVDYESE EEEEKEGEEN
DDEDTQEEGN AHGEGAQETQ EQDEEMASGA EEAPSLPALL TQPRKSTHSQ EPQGAEASKH
RVQAVREIHS FIEDYQYDTE ESLWCQVTVK LPLMKINFDM SSLVVSLAHD AIVYTTKGIT
RCLLNETTNS KNEKELVLNT EGINLPELFK YAEILDLHRL YSNDIHAMAN TYGIEAALRV
IEKEIKDVFA VYGIAVDPRH LSLVADYMCF EGVYKPLNRF GIQSNSSPLQ QMTFETSFQF
LKQATMLGSH DELRSPSACL VVGKVVKGGT GLFELKQPLR
//
