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Database: UniProt
Entry: F7HJH0_CALJA
LinkDB: F7HJH0_CALJA
Original site: F7HJH0_CALJA 
ID   F7HJH0_CALJA            Unreviewed;      1933 AA.
AC   F7HJH0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   10-MAY-2017, entry version 42.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSCJAP00000036134};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000036134, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000036134, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000036134}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000036134}.
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DR   EMBL; ACFV01093115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01093116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01093117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01093118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01093119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01093120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01093121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9483.ENSCJAP00000036134; -.
DR   Ensembl; ENSCJAT00000038160; ENSCJAP00000036134; ENSCJAG00000019443.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7HJH0; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 5.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    400    427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    868    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    955    981       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1189   1207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1228   1250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1256   1276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1305   1331       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1429   1452       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1511   1529       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1541   1559       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1571   1591       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1727   1753       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    433       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      759    985       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      995   1183       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1187   1460       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1510   1590       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1668   1763       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      438    465       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1933 AA;  218157 MW;  9704D5E74B6382EA CRC64;
     PSLATVVPLG PECLRPFTRE SLAAIEQRVV EEEARLQRNK QMEIEEPERK PRSDLEAGKN
     LPMIYGDPPP EAIGIPLEDL DPYYCDKKTF IVLNKGKAIF RFSATPALYM LSPFSMVRRG
     AIKVLIHTLF SMFIMITILT NCVFMTMSNP PPWSKNVEYT FTGIYTFESL IKILARGFCV
     DDFTFLRDPW NWLDFSVIMM AYLTEFVDLG NISALRTFRV LRALKTITVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALVGLQLFM GNLRHKCVRW PPPFNDTNTT WYSNDSWYGN
     DTCHASWATN DTFDWDAYIN DEGNFYFLEG SNDALLCGNS SDAGHCPEGY ECIKAGRNPN
     YGYTSYDTFS WAFLALFRLM TQDYWENLFQ LTLRAAGKTY MIFFVVIIFL GSFYLINLIL
     AVVAMAYAEQ NEATLAEDKE KEEEFQQMLE KFKKHQEELE KVQKEQKAPA GSFAGGGGGH
     PSSRKSAKAA QALEGGEADG DPAHGKDCNG SLDTSPGEKE APRQSGSGDS GISDAMEGEC
     LGPCAHLGSV GPGWPGFRRT GMPWKVSALG PLYPFRLLRV KVNGQKSDSA QPESPIPVPP
     TKFQKNKDVM RGVNRHKGSS HPHPWHEPRV SNGLPRLGQG HSCSTPRPGG GGAASSHGPC
     TALMALGWQE QGVFPEGDSE SRARSGGCSL RLWSLEMATL RGRGFGVPAT IPLPELEEAH
     QKCPPWWYKC AHKVLIWNCC APWVKFKNII HLIVMDPFVD LGITICIVLN TLFMAMEHYP
     MTEHFDRPHL TTPQVFTGIF TAEMVLKLIA MDPYEYFQQG WNIFDSIIVT LSLVELGLAN
     VQGLSVLRSF PLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL
     FGKSYKECVC KIASDCSLPR WHMHDFFHSF LIVFRILCGE WIETMWDCME VAGQAMCLTV
     FLMVMVIGNL VVLNLFLALL LSSFSADSLA ASDEDGEMNN LQIAIGRIKW GISFAKAFLL
     GLLHGKILSA KDIMDEKKEP PEEDLKKDNH ILNHVGLADG PPSSIELDHL NFINNPYLTI
     QVPIASEESD LEMPTEEETD TFSEPEDGKK PPQPLYDGNS SVCSTADYKP PEEDPEEQAE
     ENPEEQPEEC FTEACVQRWP CLYVDISQGR GKKWWTLRRA CFKIVEHNWF ETFIVFMILL
     SSGALAFEDI YIEQRRVIRT ILEYADKVFT YIFIMEMLLK WVAYGFKVYF TNAWCWLDFL
     IVDVSIISLV ANWLGYSELG PIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV
     LLVCLIFWLI FSIMGVNLFA GKFYYCINTT TSERFDISEV NNKSECESLM HTGQVRWLNV
     KVNYDNVGLG YLSLLQVATF KGWMDIMYAA VDSREKEEQP QYEVNLYMYL YFVIFIIFGS
     FFTLNLFIGV IIDNFNQQKK KFGGKDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPQNKIQ
     AMVYDLVTKQ VFDITIMILI CLNMVTMMVE TDDQSQLKVD ILYNINMIFI IIFTGECVLK
     MLALRQYYFT VGWNIFDFVV VILSIVAMTF ANSIENGALP SPTSSYLTSS SIGAKLQPLA
     PRPLGEPSHH LFSHLPQWWH PRYLLTVGLG LSDLNQKYFV YPRCAACIDD MFNFETFGNS
     IICLFEITTS AGWDGLLNPI LNSGPPDCDP SLENPGTSIK GDCGNPSIGI CFFCSYIIIS
     FLIVVNMYIA IILENFNVAT EESSEPLGED DFEMFYETWE KFDPDATQFI AYNRLSDFVD
     TLQEPLRIAK PNKIKLITLD LPMVPGDKIH CLDILFALTK EVLGDSGEMD ALKQTMEEKF
     MAANPSKVSY EPITTTLKRK HEEVCAIKIQ RAYRRHLLQR SMKQASYMYR HSHDGSGDDA
     PEKEGLLANT MGK
//
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