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Database: UniProt
Entry: F7HMC6_MACMU
LinkDB: F7HMC6_MACMU
Original site: F7HMC6_MACMU 
ID   F7HMC6_MACMU            Unreviewed;      2280 AA.
AC   F7HMC6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   25-OCT-2017, entry version 42.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSMMUP00000012043};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000012043, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000012043, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000012043,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000012043}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000012043};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000012043}.
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DR   EMBL; JSUE03013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03013746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000012846; ENSMMUP00000012043; ENSMMUG00000009187.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000006718; Chromosome 15.
DR   Bgee; ENSMMUG00000009187; -.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     85    102       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    154    172       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    209    231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    286    307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    319    343       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    459    479       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    485    502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    523    541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    584    606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    662    684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1126   1144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1164   1184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1196   1214       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1257   1279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1338   1363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1419   1437       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1449   1472       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1484   1508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1529   1558       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1627   1650       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1666   1701       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      687    713       {ECO:0000256|SAM:Coils}.
FT   COILED      967    994       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2280 AA;  255599 MW;  AFED5A032416DF14 CRC64;
     MRARGGGAGG AGGPGPGGLQ PGQRVLYKQS IAQRARTMAL YNPIPVKQNC FTVNRSLFVF
     SEDNVVRKYA KRITEWPYPS GRGRYMILAT IIANCIVLAL EQHLPDGDKT PMSERLDDTE
     PYFIGIFCFE AGIKIIALGF VFHKGSYLRN GWNVMDFVVV LTGILATAGT DFDLRTLRAV
     RVLRPLKLVS GIPSLQVVLK SIMKAMVPLL QIGLLLFFAI LMFAIIGLEF YMGKFHKACF
     PNSTDAEPVG DFPCGKEAPA RLCEGDTECR EYWPGPNFGI TNFDNILFAI LTVFQCITME
     GWTDILYNTN DAAGNTWNWL YFIPLIIIGS FFMLNLVLGV LSGETASKKK KKKELRRQSL
     PDRDVPLSWD EVMLAEEDRN AEEKSPLDAV LKRAATKKSR NDLIHAEEGE DRFADLCAVG
     SPFARASLKS GKTESSSYFR RKEKMFRFFI RRMVKAQSFY WVVLCVVALN TLCVAMVHYN
     QPRRLTTALY FAEFVFLGLF LTEMSLKMYG LGPRSYFRSS FNCFDFGVIV GSVFEVVWAA
     IKPGSSFGIS VLRALRLLRI FKVTKYWSSL RNLVVSLLNS MKSIISLLFL LFLFIVVFAL
     LGMQLFGGQF NFQDETPTTN FDTFPAAILT VFQILTGEDW NAVMYHGIES QGGVSKGMFS
     SFYFIVLTLF GNYTLLNVFL AIAVDNLANA QELTKDEEEM EEAANQKLAL QKAKEVAEVS
     PMSAANISIA ARQQNSAKAR SVWEQRASQL RLQNLRASCE ALYSEMDPEE RRRFATTRHL
     RPDMKTHLDR PLVVELGREG ARGPVGGKAR PEAAEAPEGV DPPRRHHRHR DKDKTPAAGD
     QDRAEAPKAE SGEPVAREER PRPHRSHSKE AAGPPEARSE RGRGPGPEGG RRHHRRGSPE
     EAPEREPRRH RAHRHQDPNK ECAGAKGERR ARHRGGPRAG PREVESGEEP ARRHRARHKA
     QPAHEAVEKE ATEKEATEKE AEIVEADKEK ELRNHQPREP HCDLETSGMV TVGPMHTLPS
     TCLQKVEEQP EDADNQRNVT RMGSQPPDPS TVVHIPVMLT GPPGEATVVP SGNVDLESQT
     EGKKEVEADD VMRSGPRPIV PYSSMFCLSP TNLLRRFCHY IVTMRYFEMV ILVVIALSSI
     ALAAEDPVHT DSPRNNALKY LDYIFTGVFT FEMVIKMIDL GLLLHPGAYF RDLWNILDFI
     VVSGALVAFA FSGSKGKDIN TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI
     LIVYMLFMFI FAVIAVQLFK GKFFYCTDES KELERDCRQH WEFPWDQVEL VTWVLKHSVD
     ATYEEQGPSP GYRMELSIFY VVYFVVFPFF FVNIFVALII ITFQEQGDKV MSECSLEKNE
     RACIDFAISA KPLTRYMPQN RQSFQYKTWT FVVSPPFEYF IMAMIALNTV VLMMKFYDAP
     YEYELMLKCL NIVFTSMFSM ECVLKIIAFG VLNYFRDAWN VFDFVTVLGS ITDILVTEIA
     NNFINLSFLR LFRAARLIKL LRQGYTIRIL LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM
     QVFGNIALDD DTSINRHNNF RTFLQALMLL FRSATGEAWH EIMLSCLSNQ ACDEQANATE
     CGSDFAYFYF VSFIFLCSFL MLNLFVAVIM DNFEYLTRDS SILGPHHLDE FIRVWAEYDP
     AACGRISYND MFEMLKHMSP PLGLGKKCPA RVAYKRLVRM NMPISSEDMT VHFTSTLMAL
     IRTALEIKLA PAGTKQHQCD AELRKEISVV WANLPQKTLD LLVPPHKPDE MTVGKVYAAL
     MIFDFYKQNK TTRDQMHQAP GGLSQMGPVS LFHPLKATLE QTQPAVLRGA RVFLRQKSST
     SLSNGGAIQN QESGIKESVS WGTQRTQDGP HEARPPLERG HSTEIPVGQS GALAVDVQMQ
     SMTRRGPDGE PQPGLESQGR AASMPRLAAE TQPVTDASPM KRSISTLAQR PRGTHLCSTT
     PDRPPPSQAP HHHHHRCHRR RDRKQRSLEK GPSLSADTDG APSSASGPGL PPGEGPTGCR
     RERERRQERG RSQERRQPSS SSSEKQRFYS CDRFGGREPP KPKPSLSSHP TSPTAGQEPG
     PHPQGSGSVN GSPLLSTSGA STPGRGGRRQ LPQTPLTPRP SITYKTANSS PIHFAGAQTS
     LPAFSPGRLS RGLSEHNALL QKDPLSQPLA PGSRIGSDPY LGQRLDSEAS VHALPEDTLT
     FEEAVATNSG RSSRTSYVSS LTSQSHPLRR VPNGYHCTLG LSSGGRARHS YHHPDQDHWC
//
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