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Database: UniProt
Entry: F7HMW2_MACMU
LinkDB: F7HMW2_MACMU
Original site: F7HMW2_MACMU 
ID   F7HMW2_MACMU            Unreviewed;      1850 AA.
AC   F7HMW2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   05-JUL-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSMMUP00000003651};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003651, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000003651, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003651,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000003651}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003651};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000003651}.
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DR   EMBL; JSUE03009014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000003862; ENSMMUP00000003651; ENSMMUG00000002712.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7HMW2; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000006718; Chromosome 12.
DR   Bgee; ENSMMUG00000002712; -.
DR   ExpressionAtlas; F7HMW2; baseline.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    372    399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    722    746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    758    779       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    841    869       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    931    954       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1180   1198       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1219   1241       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1247   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1296   1322       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1420   1444       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1520       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1557   1582       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1619   1647       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1723   1746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      134    406       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      480    680       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      731    959       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      968   1174       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1178   1452       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1501   1756       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      396    441       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1850 AA;  210058 MW;  FD438784CF5B6E18 CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
     LAIKILVHSY PFSNRIYTFE SLIKILARGF CLEDFTFLRD PWNWLDFTVI TFAYVTEFVD
     LGNVSALRTF RVLRALKTIS VIPGLKTIVG ALIQSVKKLS DVMILTVFCL SVFALIGLQL
     FMGNLRNKCL QWPPDNSSFE INITSFFNNS LDGNGTTFNR TVSMFNWDEY IEDKSHFYFL
     EGQNDALLCG NSSDAGQCPE GYICVKAGRN PNYGYTSFDT FSWAFLSLFR LMTQDFWENL
     YQLTLRAAGK TYMIFFVLVI FLGSFYLINL ILAVVAMAYE EQNQATLEEA EQKEAEFQQM
     LEQLKKQQEE AQAAAAAASA ESRDFSGAGG IGVFSESSSV ASKLSSKSEK ELKNRRKKKK
     QKEQSGEEEK NDRVRKSESE DSIRRKGFRF SLEGSRLTYE KRFSSPHQSL LSIRGSLFSP
     RRNSRASLFS FRGRTKDIGS ENDFADDEHS TFEDNDSRRD SLFVPHRHGE RRHSNVSQAS
     RASRVLPILP MNGKMHSAVD CNGVVSLVGG PSTLTSAGQL LPEGTTTETE IRKRRSSSYH
     VSMDLLEDPT SRQRAMSIAS ILTNTMEELE ESRQKCPPCW YKFANMCLIW DCCKPWLKVK
     HLVNLVVMDP FVDLAITICI VLNTLFMAME HYPMTEQFSS VLSVGNLVFT GIFTAEMFLK
     IIAMDPYYYF QEGWNIFDGF IVSLSLMELG LANVEGLSVL RSFRLLRVFK LAKSWPTLNM
     LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG MQLFGKSYKE CVCKISNDCE LPRWHMHDFF
     HSFLIVFRVL CGEWIETMWD CMEVAGQTMC LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD
     NLAATDDDNE MNNLQIAVGR MQKGIDFVKR KIREFIQKAF VRKQKALDEI KPLEDLNNKK
     DSCISNHTTI EIGKDLNYLK DGNGTTSGIG SSVEKYVVDE SDYMSFINNP SLTVTVPIAV
     GESDFENLNT EEFSSESDME ESKEKLNATS SSEGSTVDIG APAEGEQPEV EPEESLEPEA
     CFTEDCVRKF KCCQISIEEG KGKLWWNLRK TCYKIVEHNW FETFIVFMIL LSSGALAFED
     IYIEQRKTIK TMLEYADKVF TYIFILEMLL KWVAYGFQVY FTNAWCWLDF LIVDVSLVSL
     TANALGYSEL GAIKSLRTLR ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL
     IFSIMGVNLF AGKFYHCINY TTGEMFDVSV VNNYSECKAL IESNQTARWK NVKVNFDNVG
     LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI
     GVIIDNFNQQ KKKISQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPANKF QGMVFDFVTK
     QVFDISIMIL ICLNMVTMMV ETDDQSQEMT NILYWINLVF IVLFTGECVL KLISLRYYYF
     TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL
     FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG IDDMFNFETF GNSMICLFQI
     TTSAGWDGLL APILNSGPPD CDPEKDHPGS SVKGDCGNPS VGIFFFVSYI IISFLVVVNM
     YIAVILENFS VATEESAEPL SEDDFEMFYE VWEKFDPDAT QFIEFAKLSD FADALDPPLL
     IAKPNKVQLI AMDLPMVSGG LCQTDCFYKC ILKVSAYNKT ETSGQQTGTQ
//
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