ID F7HNF3_MACMU Unreviewed; 1524 AA.
AC F7HNF3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=ERCC excision repair 6 like 2 {ECO:0000313|Ensembl:ENSMMUP00000015476.4};
GN Name=ERCC6L2 {ECO:0000313|Ensembl:ENSMMUP00000015476.4,
GN ECO:0000313|VGNC:VGNC:101479};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000015476.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000015476.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000015476.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR SMR; F7HNF3; -.
DR PaxDb; 9544-ENSMMUP00000015476; -.
DR Ensembl; ENSMMUT00000016520.4; ENSMMUP00000015476.4; ENSMMUG00000011787.4.
DR VEuPathDB; HostDB:ENSMMUG00000011787; -.
DR VGNC; VGNC:101479; ERCC6L2.
DR eggNOG; KOG0387; Eukaryota.
DR GeneTree; ENSGT00940000163752; -.
DR HOGENOM; CLU_000315_17_10_1; -.
DR TreeFam; TF351516; -.
DR Proteomes; UP000006718; Chromosome 15.
DR Bgee; ENSMMUG00000011787; Expressed in ileum and 22 other cell types or tissues.
DR ExpressionAtlas; F7HNF3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18005; DEXHc_ERCC6L2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029256; Heliccase-ass-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF14773; VIGSSK; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 135..321
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 512..662
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 870..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1314..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1504..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1524 AA; 172871 MW; 54047E019DE94DAC CRC64;
MDPSAPQPCA ETAGKDIWHP GERCLAPSPD NGKLREASIK SVTVDENGKS FAVVLYSDFQ
ERKIPLKQLQ EVKFVKDCPR NLIFDDEDLE KPYFPNRKFP SSSVAFKLSD DGDSIPYTVN
RYLRDYQREG AQFLYGHYIH GRGCILGDDM GLGKTVQVIS FLAAVLHKKG TREDIENNRP
EFLLRGMKKE PPSSAAKKMF LIVAPLSVLY NWKDELDTWG YFRVTILHGN RKDNELIRVK
QRKCEIALTT YETLRLCLDE LNSLEWSAVI VDEAHRIKNP KARITEVMKA LKCNVRIGLT
GTILQNNMKE LWCVMDWAVP GLLGTRTCFK KQFSDPVEHG QRHTATKREL ATGRKAMQRL
ARRMSGWFLR RTKALIKDQL PKKEDRMVYC SLTDFQKAVY QTVLETEDVT LILQSSEPCT
CRSGRKRRNC CYKTNSHGET VKTLYLSYLT VLQKVANHVA LLQAASTSKQ QETLIKRICD
QVFSRFPDFV QKSKDAAFET LSDPKYSGKM KVLQQLLNHC RKNRDKVLLF SFSTKLLDVL
QQYCMASGLD YRRLDGSTKS EERLKIVKEF NSTQDVNICL VSTMAGGLGL NFVGANVVVL
FDPTWNPAND LQAIDRAYRI GQCRDVKVLR LISLGTVEEI MYLRQVYKQQ LHCVVVGSEN
AKRYFEAVQG SKEHQGELFG IHNLFKLRSQ GSCLTRDILE PGEPDCQECR GPEQAAEPLA
KEVCDPCSDF SDEEPVGAAG VKTAKNRAPD SNKASSSPGQ LTLLQCGFSK LFETKCKAVE
DSDGNTASDD ESSDEQPTCL STEAKDAGCE KNQDSLCTSK YQKLGNILNP KEKHIFYKSE
KTLEQSISSK SDEKKFKNTD KHCILQNDTE SEDSDVICPT QHTTERFPDN SIRFKPPLEG
SEDSETEHSV KTRNNDNGRK TDDQRNGIIS EKLSPENTTL KCIVKRKGTS DISDESDDIE
ISSKSRVRKS SLRFKRIKET KKELHNSPKT VNKTNQVYAT NEDHNSQFID DYSSSDESLS
VSHFSFSKQS HRTRTVKDRT SFSSKLPSHN KKSSTVMPRK PMKCSNEKAV NQEQSYESMD
KFLDGVQEVA YIHSNQNVIG SSKAENHMSR WAAHDVFELK QFSQLPANIA VCSSKTYKEK
VNANTLPHTK KGQQPSEGSI SLPLYISHPV SQKKKKVYRT NQTTFIIGET PKGIRRKQFE
EMASYFNSSS VNEFAEHITS ATSEERQKML RDFYASQYPE VKELFMDSAS EFNTSSFEKG
ECTRKKSEKR DSLIKARLSD SETLSFKDST NKISQVCSLK TYKRKSIKFQ NHSSCREEVY
SNDAETKKSP VSSTQKTDSG KNSQASKDTV TSRSQNSESE THERRLENTM KDKQDLTRMG
ISRKEPLLKL ENKKIENPVL ENSSVISLLG DTSILDDLFR SHGNSPTQLP KQVLSGPVEK
AKQRPKDFWD ILNEQNDESL NKLTDLAVIE TLCEKAPLAA PSKRREEPAT PLWKSNEKFL
WKKFNSSSTD ENTTNTQSTT EVYK
//
