ID F7I0Q4_CALJA Unreviewed; 843 AA.
AC F7I0Q4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO4C1 {ECO:0000313|Ensembl:ENSCJAP00000017413.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000017413.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000017413.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000017413.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7I0Q4; -.
DR STRING; 9483.ENSCJAP00000017413; -.
DR Ensembl; ENSCJAT00000018415.4; ENSCJAP00000017413.4; ENSCJAG00000009487.4.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01080000257410; -.
DR HOGENOM; CLU_008954_1_2_1; -.
DR InParanoid; F7I0Q4; -.
DR OMA; QFFSGEY; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000009487; Expressed in kidney and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd17463; MFS_SLCO4C_OATP4C; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF103; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4C1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 292..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 347..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 384..411
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 501..524
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 536..562
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 574..592
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 696..722
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 786..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 226..797
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 613..668
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 94..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 92374 MW; C1881F9B3CBF44CB CRC64;
MTGKKSYQDA HESKAYLRRL ESWISSLAWF GKQQRKKNAR HFLEQSSDAT VFTGFMPAPR
GSFWKEAPTV SVCYQRLGFR EARWGWRLRS EPPELGQRRT SVDGDELRTL APSTGQRPGG
TPTPRLPVGS CGDSPDNLRR SSASPPQIEV SVFSSDPQRE NSQPQELQKP QGPQKSLEPP
LPSAPPNASE EQPRSMSLSE FEEGPCGWRN LHPQCLQRCN TPQGFLLHYC LLAVTQGMIV
NGLVNISIST IEKRYEMKSS LTGLISSSYD ISFCLLSLFV SFFGERGHKP RWLAFAAFMI
GLGALVFSLP QFFSGEYQLG SPFEDTCITT RNSTSCTSST SSLSNYLYVF ILGQLLLGAG
GTPLYTLGTA FLDDSVPTHK SSLYIGTGYA MSILGPAIGY VLGGQLLTMY IDVAMGESTE
VTEDDPRWLG AWWIGFILSW IFAWSLIIPF SCFPKHLPGT AEIQAGKTSQ AHQIGSNIDE
KFGKSIKDFP AALKNLMKNG VFVCLVLSTS SEALITTGFA TFLPKFIENQ FGLTPSFAAT
LGGAVLIPGA ALGQILGGVL VSKFKMTCKN TMKFALFTSG VALMLSFVLI YAKCENEPFA
GVSESYNGTG ELGNLVASCN TNCNCLQSYY YPVCGEDGVQ YFSPCFAGCS DSVSHRKPKV
YYNCSCIERK TEITSTAETF GSEAKAGKCE THCANLPIFL CIFFIIIIFT FMAGTPITVS
ILRCVNHRQR SLALGIQFTL LRLLGTIPGP IIFGITIDST CILWDINDCG IKGACWIYNN
IKMAHMLVTI SVTCKVITIF FNGFAIFLYK PPLSATDVSF HNQNAVVTNV LAEQDLNRVG
KEG
//
