ID F7I734_CALJA Unreviewed; 215 AA.
AC F7I734;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Sodium channel subunit beta-3 {ECO:0000256|ARBA:ARBA00017320};
GN Name=SCN3B {ECO:0000313|EMBL:JAB12730.1,
GN ECO:0000313|Ensembl:ENSCJAP00000014398.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000014398.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000014398.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB12730.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51298.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB27460.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB12730.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB37138.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000014398.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Modulates channel gating kinetics. Causes unique persistent
CC sodium currents. Inactivates the sodium channel opening more slowly
CC than the subunit beta-1. Its association with NFASC may target the
CC sodium channels to the nodes of Ranvier of developing axons and retain
CC these channels at the nodes in mature myelinated axons.
CC {ECO:0000256|ARBA:ARBA00025204}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN3B (TC
CC 8.A.17) family. {ECO:0000256|ARBA:ARBA00010404}.
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DR EMBL; GAMS01010406; JAB12730.1; -; mRNA.
DR EMBL; GAMR01006472; JAB27460.1; -; mRNA.
DR EMBL; GAMR01006471; JAB27461.1; -; mRNA.
DR EMBL; GAMQ01004713; JAB37138.1; -; mRNA.
DR EMBL; GAMP01001457; JAB51298.1; -; mRNA.
DR EMBL; GAMP01001456; JAB51299.1; -; mRNA.
DR RefSeq; XP_009005266.1; XM_009007018.2.
DR RefSeq; XP_009005267.1; XM_009007019.2.
DR RefSeq; XP_009005268.1; XM_009007020.2.
DR STRING; 9483.ENSCJAP00000014398; -.
DR Ensembl; ENSCJAT00000015174.4; ENSCJAP00000014398.1; ENSCJAG00000007754.5.
DR GeneID; 100392603; -.
DR KEGG; cjc:100392603; -.
DR CTD; 55800; -.
DR GeneTree; ENSGT00390000018560; -.
DR OMA; QGSHMKL; -.
DR OrthoDB; 3036301at2759; -.
DR Proteomes; UP000008225; Chromosome 11.
DR Bgee; ENSCJAG00000007754; Expressed in frontal cortex and 1 other cell type or tissue.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR027098; Na_channel_b1/b3.
DR PANTHER; PTHR10546; SODIUM CHANNEL SUBUNIT BETA-1 AND 3; 1.
DR PANTHER; PTHR10546:SF1; SODIUM CHANNEL SUBUNIT BETA-3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:JAB12730.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..215
FT /note="Sodium channel subunit beta-3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014091320"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 215 AA; 24702 MW; 70F6C604E9E26662 CRC64;
MPAFNRLFPL ASLVLIYWVS VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV
EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC
NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLLIEMIYC
YRKVSKAEEA AQENASDYLA IPSENKENSA VPVEE
//
