ID F7IAB0_CALJA Unreviewed; 1291 AA.
AC F7IAB0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSCJAP00000031460.4};
GN Name=NFASC {ECO:0000313|Ensembl:ENSCJAP00000031460.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031460.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000031460.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000031460.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR Ensembl; ENSCJAT00000033255.4; ENSCJAP00000031460.4; ENSCJAG00000017046.5.
DR GeneTree; ENSGT00940000157024; -.
DR HOGENOM; CLU_005756_2_0_1; -.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000008225; Chromosome 19.
DR Bgee; ENSCJAG00000017046; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR CDD; cd05875; IgI_hNeurofascin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR InterPro; IPR026965; NFASC_Ig-like.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1161..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 357..445
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 450..537
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 542..630
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 634..716
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 743..838
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 843..936
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 941..1043
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1047..1143
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1291 AA; 144503 MW; 682A5B583A470A07 CRC64;
MRRLAARGAA GDAGEVAAPA AGGSDSAQAR SPSPWRLIDL GAIWNTGVFL PAAAWNGASS
GVERRRLNEA KKLSSVQKVQ LKRLKVTRPR GLGNREWGRV PRMARQPAPP WVHAAFLLCL
LSLGGAIEIP MDLTQPPTIT KQSVKDHIVD PRDNILIECE AKGNPAPSFH WTRNSRFFNI
AKDPRVSMRR RSGTLVIDFR SGGRPEEYEG EYQCFARNKF GTALSNRIRL QVSKSPLWPK
ENLDPVVVQE GAPLTLQCNP PPGLPSPVIF WMSSSMEPIA QDKRVSQGHN GDLYFSNVML
QDMQTDYSCN ARFHFTHTIQ QKNPFTLKVL TNHPYNDSSL RNHPDMYSAR GVAERTPSFM
YPQGTASSQM VLRGMDLLLE CIASGVPTPD IAWYKKGGDL PSDKAKFENF NKALRITNVS
EEDSGEYFCL ASNKMGSIRH TISVRVKAAP YWLDEPKNLI LAPGEDGRLV CRANGNPKPT
VQWMVNGEPL QSAPPNPNRE VAGDTIIFRD TQISSRAVYQ CNTSNEHGYL LANAFVSVLD
VPPRMLSPRN QLIRVILYNR TRLDCPFFGS PIPTLRWFKN GQGSNLDGGN YHVYENGSLE
IKMIRKEDQG IYTCVATNIL GKAENQVRLE VKDPTRIYRM PEDQVAKRGT TVQLECRVKH
DPSLKLTVSW LKDDEPLYIG NRMKKEDDSL TIFGVAERDQ GSYTCVASTE LDQDLAKAYL
TVLADQATPT NRLAALPKGR PDRPRDLELT DLAERSVRLT WIPGDDNNSP ITDYVVQFEE
DQFQPGVWHD HSKYPGSVNS AVLRLSPYVN YQFRVIAINE VGSSHPSLPS ERYRTSGAPP
ESNPGDVKGE GTRKNNMEIT WTPMNATSAF GPNLRYIVKW RRRETREAWN NVTVWGSRYV
VGQTPVYVPY EIRVQAENDF GKGPEPESVI GYSGEDYPRA APTEVKVRVV NSTAINLQWN
RVYPDTVQGQ LREYRAYYWR ESSLLKNLWV SQKRQQASFP GDRLRGVVSR LFPYSNYKLE
MVVVNGRGDG PRSETKEFTT PEGVPSAPRR FRVRQPNLET INLEWDHPEH PNGIMLGYTL
KYVAFNGTKV GKQIVENFSP NQTKFVVQRT DPVSRYRFTL SARTQVGSGE AVTEESPAPP
NEATPTAAYT NNQADIATQG WFIGLMCAIA LLVLILLIVC FIKRSRGGKY PVREKKDVPL
GPEDPKEEDG SFDYSDEDNK PLQGSQTSLD GTIKQQESDD SLVDYGEGGE GQFNEDGSFI
GQYTVKKDKD ETEGNESSEA TSPVNAIYSL A
//
