ID   F7IAM1_CALJA            Unreviewed;       946 AA.
AC   F7IAM1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=116 kDa U5 small nuclear ribonucleoprotein component {ECO:0000256|ARBA:ARBA00018774};
DE   AltName: Full=U5 snRNP-specific protein, 116 kDa {ECO:0000256|ARBA:ARBA00031432};
GN   Name=EFTUD2 {ECO:0000313|Ensembl:ENSCJAP00000022955.4};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000022955.4, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000022955.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000022955.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; F7IAM1; -.
DR   Ensembl; ENSCJAT00000024291.5; ENSCJAP00000022955.4; ENSCJAG00000012349.5.
DR   eggNOG; KOG0468; Eukaryota.
DR   GeneTree; ENSGT00940000155685; -.
DR   HOGENOM; CLU_002794_11_2_1; -.
DR   TreeFam; TF105703; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   Bgee; ENSCJAG00000012349; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd04098; eEF2_C_snRNP; 1.
DR   CDD; cd04090; EF2_II_snRNP; 1.
DR   CDD; cd01683; EF2_IV_snRNP; 1.
DR   CDD; cd16264; snRNP_III; 1.
DR   CDD; cd04167; Snu114p; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.240; -; 1.
DR   Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR031950; EFTUD2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   InterPro; IPR044121; Snu114_GTP-bd.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   InterPro; IPR035655; U5-116kDa_C.
DR   PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR   PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF16004; EFTUD2; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   4: Predicted;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT   DOMAIN          86..383
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..49
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  106459 MW;  95DB76264ACA9534 CRC64;
     MDTDLYDEFG NYIGPELDSD EDDDELGRET KDLDEMDDDD DDDDIGDHDD DHPGMEVVLH
     EDKKYYPTAE EVYGPEVETI VQEEDTQPLT EPIIKPVKTK KFTLMELLTL CAGMLWTCFV
     DCLIEQTHPE IRKRYDQDLC YTDILFTEQE RGVGIKSTPV TVVLPDTKGK SYLFNIMDTP
     GHVNFSDEVT AGLRISDGVV LFIDAAEGVM LNTERLIKHA VQERLAVTVC INKIDRLILE
     LKLPPTDAYY KLRHIVDEVN GLISMYSTDE NLILSPLLGN VCFSSSQYSI CFTLGSFAKI
     YADTFGDINY QEFAKRLWGD IYFNPKTRKF TKKAPTSSSQ RSFVEFILEP LYKILAQVVG
     DVDTSLPRTL DELGIHLTKE ELKLNIRPLL RLVCKKFFGE FTGFVDMCVQ HIPSPKVGAK
     PKIEHTYTGG VDSDLGEAMS DCDPDGPLMC HTTKMYSTDD GVQFHAFGRV LSGTIHAGQP
     VKVLGENYTL EDEEDSQICT VGRLWISVAR YHIEVNRVPA GNWVLIEGVD QPIVKTATIT
     EPRGNEEAQI FRPLKFNTTS VIKIAVEPVN PSELPKMLDG LRKVNKSYPS LTTKVEESGE
     HVILGTGELY LDCVMHDLRK MYSEIDIKVA DPVVTFCETV VETSSLKCFA ETPNKKNKIT
     MIAEPLEKGL AEDIENEVVQ ITWNRKKLGE FFQTKYDWDL LAARSIWAFG PDATGPNILV
     DDTLPSEVDK ALLGSVKDSI VQGFQWGTRE GPLCDELIRN VKFKILDAVV AQEPLHRGGG
     QIIPTARRVV YSAFLMATPR LMEPYYFVEV QAPADCVSAV YTVLARRRGH VTQDAPIPGS
     PLYTIKAFIP AIDSFGFETD LRTHTQGQAF SLSVFHHWQI VPGDPLDKSI VIRPLEPQPA
     PHLAREFMIK TRRRKGLSED VSISKFFDDP MLLELAKQDV VLNYPM
//