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Database: UniProt
Entry: F7IDA9_CALJA
LinkDB: F7IDA9_CALJA
Original site: F7IDA9_CALJA 
ID   F7IDA9_CALJA            Unreviewed;      2005 AA.
AC   F7IDA9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUL-2017, entry version 47.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN2A {ECO:0000313|EMBL:JAB52531.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000011518};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011518, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000011518, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000011518}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAB52531.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:JAB52531.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen
RT   mRNA sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; ACFV01062060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GAMP01000224; JAB52531.1; -; mRNA.
DR   RefSeq; XP_002749429.1; XM_002749383.3.
DR   RefSeq; XP_002749430.1; XM_002749384.3.
DR   Ensembl; ENSCJAT00000011873; ENSCJAP00000011251; ENSCJAG00000006141.
DR   Ensembl; ENSCJAT00000012151; ENSCJAP00000011518; ENSCJAG00000006141.
DR   GeneID; 100389294; -.
DR   KEGG; cjc:100389294; -.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   KO; K04834; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000008225; Chromosome 6.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0033270; C:paranode region of axon; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:JAB52531.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    401    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    751    775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    808       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    870    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    960    983       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1209   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1449   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1587   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1753   1776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    435       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      509    709       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      760    988       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      997   1203       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1481       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1786       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      425    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2005 AA;  227954 MW;  F057EBD637F8D203 CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
     LAIKILVHSL FNMLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC
     LEDFTFLRDP WNWLDFTVIT FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSSFEI NITSFFNNSL
     DGNGTTFNRT VSMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP
     NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI
     LAVVAMAYEE QNQATLEEAE QKEAEFQQML EQLKKQQEEA QAAAAAASAE SRDFSGAGGI
     GVFSESSSVA SKLSSKSEKE LKNRRKKKKQ KEQSGEEEKS DRVRKSESED SIRKKGFRFS
     LEGSRLTYEK RFSSPHQSLL SIRGSLFSPR RNSRASLFSF RGRTKDIGSE NDFADDEHST
     FEDNDSRRDS LFVPHRHGER RHSNVSQASR ASRVLPILPM NGKMHSAVDC NGVVSLVGGP
     STLTSAGQLL PEGTTTETEI RKRRSSSYHV SMDLLEDPTS RQRAMSIASI LTNTMEELEE
     SRQKCPPCWY KFANMCLIWD CCKPWLKVKH LVNLVVMDPF VDLAITICIV LNTLFMAMEH
     YPMTEQFSSV LSVGNLVFTG IFTAEMFLKI IAMDPYYYFQ EGWNIFDGFI VSLSLMELGL
     ANVEGLSVLR SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM
     QLFGKSYKEC VCKISNDCEL PRWHMHDFFH SFLIVFRVLC GEWIETMWDC MEVAGQTMCL
     TVFMMVMVIG NLVVLNLFLA LLLSSFSSDN LAATDDDNEM NNLQIAVGRM QKGIDFVKRK
     IREFIQKAFV RKQKALDEIK PLEDLNNKKD SCISNHTTIE IGKDLNYLKD GNGTTSGIGS
     SVEKYVVDES DYMSFINNPS LTVTVPIAVG ESDFENLNTE EFSSESDMEE SKEKLNATSS
     SEGSTVDIGA PAEGEQPEAE PEESLEPEAC FTEDCVRKFK CCQISIEEGK GKLWWNLRKT
     CYKIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT YIFILEMLLK
     WVAYGFQVYF TNAWCWLDFL IVDVSLVSLT ANALGYSELG AIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL LGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCINYT TGEMFDVSVV
     NNYSECKALI ESNQTARWKN VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ
     PKYEDNLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPANKF QGMVFDFVTK QVFDISIMIL ICLNMVTMMV ETDDQSQEMT
     NILYWINLVF IVLFTGECVL KLISLRYYYF TIGWNIFDFV VVILSIVGMF LAELIEKYFV
     SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS
     NFAYVKREVG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSGPPD CDPEKDHPGS
     SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE
     VWEKFDPDAT QFIEFAKLSD FADALDPPLL IAKPNKVQLI AMDLPMVSGD RIHCLDILFA
     FTKRVLGESG EMDALRIQME ERFMASNPSK VSYEPITTTL KRKQEEVSAI IIQRAYRRYL
     LKQKVKKVSS IYKKDKGKEC DGTPIKEDTL IDKLNENSTP EKTDMTPSTT SPPSYDSVTK
     PEKEKFEKDK SEKEDKGKDI RESKK
//
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