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Database: UniProt
Entry: F7IDB7_CALJA
LinkDB: F7IDB7_CALJA
Original site: F7IDB7_CALJA 
ID   F7IDB7_CALJA            Unreviewed;      1986 AA.
AC   F7IDB7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUL-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSCJAP00000011510};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011510, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000011510, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000011510}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000011510}.
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DR   EMBL; ACFV01062060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01062065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000012143; ENSCJAP00000011510; ENSCJAG00000006141.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000008225; Chromosome 6.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    401    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    732    756       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    768    789       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    851    879       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    941    964       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1190   1208       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1229   1251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1257   1277       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1306   1332       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1430   1454       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1513   1531       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1543   1561       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1568   1593       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1630   1658       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1734   1757       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    435       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      492    690       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      741    969       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      978   1184       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1188   1462       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1512   1767       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      425    470       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1986 AA;  225619 MW;  A0233259B03B80FD CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
     LAIKILVNCL FNMLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC
     LEDFTFLRDP WNWLDFTVIT FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSSFEI NITSFFNNSL
     DGNGTTFNRT VSMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP
     NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI
     LAVVAMAYEE QNQATLEEAE QKEAEFQQML EQLKKQQEEA QAAAAAASAE SRDFSGAGGI
     GVFSESSSVA SKLSSKSEKE LDRVRKSESE DSIRKKGFRF SLEGSRLTYE KRFSSPHQSL
     LSIRGSLFSP RRNSRASLFS FRGRTKDIGS ENDFADDEHS TFEDNDSRRD SLFVPHRHGE
     RRHSNVSQAS RASRVLPILP MNGKMHSAVD CNGVVSLVGG PSTLTSAGQL LPEGTTTETE
     IRKRRSSSYH VSMDLLEDPT SRQRAMSIAS ILTNTMEELE ESRQKCPPCW YKFANMCLIW
     DCCKPWLKVK HLVNLVVMDP FVDLAITICI VLNTLFMAME HYPMTEQFSS VLSVGNLVFT
     GIFTAEMFLK IIAMDPYYYF QEGWNIFDGF IVSLSLMELG LANVEGLSVL RSFRLLRVFK
     LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG MQLFGKSYKE CVCKISNDCE
     LPRWHMHDFF HSFLIVFRVL CGEWIETMWD CMEVAGQTMC LTVFMMVMVI GNLVVLNLFL
     ALLLSSFSSD NLAATDDDNE MNNLQIAVGR MQKGIDFVKR KIREFIQKAF VRKQKALDEI
     KPLEDLNNKK DSCISNHTTI EIGKDLNYLK DGNGTTSGIG SSVEKYVVDE SDYMSFINNP
     SLTVTVPIAV GESDFENLNT EEFSSESDME ESKEKLNATS SSEGSTVDIG APAEGEQPEA
     EPEESLEPEA CFTEDCVRKF KCCQISIEEG KGKLWWNLRK TCYKIVEHNW FETFIVFMIL
     LSSGALAFED IYIEQRKTIK TMLEYADKVF TYIFILEMLL KWVAYGFQVY FTNAWCWLDF
     LIVDVSLVSL TANALGYSEL GAIKSLRTLR ALRPLRALSR FEGMRVVVNA LLGAIPSIMN
     VLLVCLIFWL IFSIMGVNLF AGKFYHCINY TTGEMFDVSV VNNYSECKAL IESNQTARWK
     NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL QPKYEDNLYM YLYFVIFIIF
     GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPANK
     FQGMVFDFVT KQVFDISIMI LICLNMVTMM VETDDQSQEM TNILYWINLV FIVLFTGECV
     LKLISLRYYY FTIGWNIFDF VVVILSIVGM FLAELIEKYF VSPTLFRVIR LARIGRILRL
     IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKREV GIDDMFNFET
     FGNSMICLFQ ITTSAGWDGL LAPILNSGPP DCDPEKDHPG SSVKGDCGNP SVGIFFFVSY
     IIISFLVVVN MYIAVILENF SVATEESAEP LSEDDFEMFY EVWEKFDPDA TQFIEFAKLS
     DFADALDPPL LIAKPNKVQL IAMDLPMVSG DRIHCLDILF AFTKRVLGES GEMDALRIQM
     EERFMASNPS KVSYEPITTT LKRKQEEVSA IIIQRAYRRY LLKQKVKKVS SIYKKDKGKE
     CDGTPIKEDT LIDKLNENST PEKTDMTPST TSPPSYDSVT KPEKEKFEKD KSEKEDKGKD
     IRESKK
//
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