ID F7IG22_CALJA Unreviewed; 503 AA.
AC F7IG22;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN Name=GFAP {ECO:0000313|Ensembl:ENSCJAP00000023044.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023044.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000023044.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000023044.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; F7IG22; -.
DR Ensembl; ENSCJAT00000024380.5; ENSCJAP00000023044.5; ENSCJAG00000012563.5.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR GeneTree; ENSGT00940000159539; -.
DR HOGENOM; CLU_012560_7_4_1; -.
DR TreeFam; TF330122; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000012563; Expressed in cerebellum and 4 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 100..408
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 20..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 104..252
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 306..379
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 503 AA; 57402 MW; FE7196B158D57AB6 CRC64;
MPGALPGAAS IASPAHSFIK PSCLRSKQSQ GRMERRRITS AARRSYVSQG EMMVGGLASR
RLGPGSRLSL ARMPPPLTTR VDFSLAGALN AGFKETRASE RAEMMELNDR FASYIEKVRF
LEQQNKALAA ELNQLRAKEP TKLADVYQAE LRELRLRLDQ LTANSARLEV ERDNLAQDLG
TVRQKLQDET NLRLEAENNL AAYRQEADEA TLARLDLERK IESLEEEIRF LRKIHEEEVR
ELQEQLARQQ VHVELDVAKP DLTAALKEIR TQYEAMASSN MHEAEEWYRS KFADLTDAAA
RNAELLRQAK HEANDYRRQL QSLTCDLESL RGTNESLERQ MREQEERHAR EAASYQEALE
RLEEEGQSLK DEMARHLQEY QDLLNVKLAL DIEIATYRKL LEGEENRITI PVQTFSNLQI
RGGKSTKDGE NHKVTRHLKS LTIRVIPIQA HQIVNGAPPA RETSLDTKSV SEGHLKRNIV
VKTVEMRDGE VIKESKQEHK DVM
//
