ID F7IGI4_CALJA Unreviewed; 873 AA.
AC F7IGI4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=BCAR1 scaffold protein, Cas family member {ECO:0000313|Ensembl:ENSCJAP00000026311.3};
GN Name=BCAR1 {ECO:0000313|Ensembl:ENSCJAP00000026311.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000026311.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000026311.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000026311.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR AlphaFoldDB; F7IGI4; -.
DR Ensembl; ENSCJAT00000027806.4; ENSCJAP00000026311.3; ENSCJAG00000014296.6.
DR GeneTree; ENSGT00950000183008; -.
DR Proteomes; UP000008225; Chromosome 20.
DR Bgee; ENSCJAG00000014296; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11569; FAT-like_BCAR1_C; 1.
DR CDD; cd12001; SH3_BCAR1; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046976; BCAR1_C.
DR InterPro; IPR035745; BCAR1_SH3.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654:SF15; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1; 1.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2..64
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 69..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 93793 MW; 7F177A5120AAC26B CRC64;
MEVNVLAKAL YDNVAESPDE LSFRKGDIMT VLEQDTQGLD GWWLCSLHGR QGIVPGNRLK
ILVGMYDKKP AGPGPGPPAA SAQPQPGLPQ SLHAPAPPTS QYTPMLPATY QPQPDSVYLV
PTPSKTQQGL YQAPGPGPQF QSPPAKQTST FSKQTPHHPF PSPATDLYQV PPGPGGPAQD
IYQVPPSAGM GHDIYQVPPS MDTRSWEGTK PPAKVVVPTR VGQGYVYEAT QPEQDEYDIP
RHLLALGPQD IYDVPPVRGL LPSQYGQEVY DTPPMAVKGP NGRAPLLEVY DVPPSVEKGL
PLSSHHAVYD VPPSVSKDVP DGPLLREETY DVPPAFAKAK PFDPTRTPLV LAAPPLDSPP
AEDVYDVPPP APDLYDVPPG LRRPGPGTLY DVPRERVLPP EVADSGAADD GVYAVPPPAE
REAPVDGKRL SASSTGSTRS SQSASSLEVA GPGREPLELE VAVEALARLQ QGVSATVAHL
LDLAGSAGGT RSWHSTPEPQ EPLVQELRAA VAAVQSAVHE LLEFARSAVG NAAHTSDRAL
HAKLSRQLQK MEDVHQTLVA HGQALDSGRG GLGATPEDLD RLVACSRAVP EDAKQLASFL
HGNASLLFRR TKAPALGPEG GGTLHPNPTD KASSIQSRPL PSPPKFTSQD SPDGQYENSE
GGWMEDYDYV HLQGKEEFEK TQKELLEKGS ITRQGKSQLE LQQLKQFERL EQEVSRPIDH
DLANWTPAQP LAPGRTGSLG PSDRQLLLFY LEQCEANLTT LTNAVDAFFT AVATNQPPKI
FVAHSKFVIL SAHKLVFIGD TLSRQAKAAD VRSQVTHYSN LLCDLLRGIV ATTKAAALQY
PSPSAAQDMV ERVKELGHST QQFRRVLGQL AAA
//
