ID F7IJ42_CALJA Unreviewed; 661 AA.
AC F7IJ42;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN Name=DUSP16 {ECO:0000313|EMBL:JAB13509.1,
GN ECO:0000313|Ensembl:ENSCJAP00000040282.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000040282.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000040282.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB13509.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51310.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB24837.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB13509.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB37283.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000040282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; GAMS01009627; JAB13509.1; -; mRNA.
DR EMBL; GAMR01009095; JAB24837.1; -; mRNA.
DR EMBL; GAMQ01004568; JAB37283.1; -; mRNA.
DR EMBL; GAMP01001445; JAB51310.1; -; mRNA.
DR RefSeq; XP_002752178.1; XM_002752132.3.
DR RefSeq; XP_009001556.1; XM_009003308.2.
DR STRING; 9483.ENSCJAP00000040282; -.
DR Ensembl; ENSCJAT00000042547.4; ENSCJAP00000040282.1; ENSCJAG00000021639.5.
DR GeneID; 100388584; -.
DR KEGG; cjc:100388584; -.
DR CTD; 80824; -.
DR eggNOG; KOG1716; Eukaryota.
DR GeneTree; ENSGT00940000157164; -.
DR HOGENOM; CLU_027074_16_0_1; -.
DR OMA; EGIMSEN; -.
DR OrthoDB; 2901840at2759; -.
DR TreeFam; TF105122; -.
DR Proteomes; UP000008225; Chromosome 9.
DR Bgee; ENSCJAG00000021639; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008432; F:JUN kinase binding; IEA:Ensembl.
DR GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0048273; F:mitogen-activated protein kinase p38 binding; IEA:Ensembl.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:Ensembl.
DR GO; GO:0045204; P:MAPK export from nucleus; IEA:Ensembl.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR CDD; cd01446; DSP_MapKP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR008343; MKP.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF343; DUAL SPECIFICITY PROTEIN PHOSPHATASE 16; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR01764; MAPKPHPHTASE.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 22..137
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 158..300
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 227..281
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 319..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 72840 MW; A49BE62265F84A6B CRC64;
MAHEMIGTQI VTERLVALLE SGTEKVLLID SRPFVEYNTS HILEAININC SKLMKRRLQQ
DKVLITELIQ HSAKHKVDID CSQKVVVYDQ SSQDVASLSS DCFLTVLLGK LEKSFNSVHL
LAGGFAEFSR CFPGLCEGKS TLVPSCISQP CLPVANIGPT RILPNLYLGC QRDVLNKELM
QQNGIGYVLN ASSTCPKPDF IPESHFLRVP VNDSFCEKIL PWLDESVDFI EKAKASNGCV
LVHCLAGISR SATIAIAYIM KRMDMSLDEA YRFVKEKRPT ISPNFNFLGQ LLDYEKKIKN
QTGTSGPKSK LKLLHLEKPN DPVPAVSEGG QKSESPLSPP SADSATSEAA GQRPVHPTSM
PSMQPPLLED SPLVQALSGL HLSTDRLEDS NKLKRSFSLD IKSVSYSASM AASLHGFSSE
DALEYYKPSS TLDGTNKLCQ FSPVQELSEQ TPETSPDKEE TSIPKKPPTT RPSDSQSKRL
HSVRTSSSGT TQRSLLSPLH RSGSVEDNYH TSFLFGLSTS QQHLTKSAGL GLKGWHSDIL
APQTSTPSLT SSWYFATESS HFYSASAIYG GSASYSAYSC SQLPTCGDQV YSVRRRQKPS
DRADSRRSWH EESPFEKQFK RRSCQMEFGE SIMSENRSRE ELGKVGSQSS FSGSMEIIEV
S
//
