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Database: UniProt
Entry: F7IP77_CALJA
LinkDB: F7IP77_CALJA
Original site: F7IP77_CALJA 
ID   F7IP77_CALJA            Unreviewed;       518 AA.
AC   F7IP77;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 42.
DE   SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSCJAP00000029287};
GN   Name=TPCN2 {ECO:0000313|Ensembl:ENSCJAP00000029287};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000029287, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000029287, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000029287}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000029287}.
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DR   EMBL; ACFV01145166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F7IP77; -.
DR   STRING; 9483.ENSCJAP00000029287; -.
DR   Ensembl; ENSCJAT00000030948; ENSCJAP00000029287; ENSCJAG00000015902.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; F7IP77; -.
DR   OMA; SSVIWVN; -.
DR   OrthoDB; EOG091G045K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000008225; Chromosome 11.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR   GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF270; PTHR10037:SF270; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     53     78       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    233    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    269    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    347    367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    405    428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    440    460       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       11     81       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      197    463       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   518 AA;  58960 MW;  E55AD29ACB38DBDE CRC64;
     MLQFAGGKQD DGQDRERLTY FRNLPESLTS LLVLLTTANN PDVMVPAYSK NRAYAIFFIV
     FTVIGDLFLM NLLTAIIYSQ FRGYLMKSLQ TSLFRRRLGT RAAFEVLSSV AGEEGAFPQA
     AGVKPQNLLQ VLQRVQLDSS HKEAMMEQVH SYGSVPLSAD EFQKLFNELD RSVVKEHPRR
     PTYQSPFLQS AQFLFGHYYF DYLGNLIALA NLVSICVFLV LDADVLPAER DDFVLGILNC
     VFIVYYLLEL LLKVFALGLR GYLSYPSNVF DGLLTIVLLV LEISTLAVYR LPHPGWRPEM
     LGLLSLWDMT RMLNMLIVFR FLRIIPNMKP MAVVASTVLG LVQNMRAFGG ILVVVYYVFA
     IIGINLFRGV IVAPLGNSSL APANGSAPCG SFEQLEYWAN NFDDFAAALV TLWNLMVVNN
     WQVLLDAFRR YSGPWSKIYF VLWWLVSSVI WVNLFLALIL ENFLHKWDPH SYLQPLAGTP
     EATYQMTVEL MFRDILEEPK EDELTETLSH HPHLRLCR
//
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