ID F7IQJ8_CALJA Unreviewed; 601 AA.
AC F7IQJ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Relaxin family peptide receptor 1 {ECO:0000313|Ensembl:ENSCJAP00000002749.3};
GN Name=RXFP1 {ECO:0000313|Ensembl:ENSCJAP00000002749.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000002749.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000002749.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000002749.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; F7IQJ8; -.
DR Ensembl; ENSCJAT00000002901.4; ENSCJAP00000002749.3; ENSCJAG00000001492.5.
DR GeneTree; ENSGT00940000158241; -.
DR HOGENOM; CLU_006130_2_1_1; -.
DR Proteomes; UP000008225; Chromosome 3.
DR Bgee; ENSCJAG00000001492; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15965; 7tmA_RXFP1_LGR7; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR008112; Relaxin_rcpt.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF68; RELAXIN RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01739; RELAXINR.
DR SMART; SM00365; LRR_SD22; 2.
DR SMART; SM00369; LRR_TYP; 8.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 254..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 266..525
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 601 AA; 69538 MW; 612C67398505E7A0 CRC64;
MVTCTQNKKA ALKFLLYHSH NLGYLQNNKI TSISVYAFRG LNSLTKLYLS HNRITFLKPG
VFEDLHRLEW LIIEDNHLSQ ISPPTFYGLN SLILLVLMNN VLTHLPDKPL CQHMPRLHWL
VMRKNKINHL NENTFAPLQK LDELDLGSNK IENLPPHVFK DLKELSQLNL SYNPIQKIQA
NQFDYLVKLK SLSLEGIEIS NIQQRMFRPL TNLSHIYFKK FQYCGYAPHV RSCKPNTDGI
SSLENLLASI IQRVFVWVVS AVTCFGNIFV ICMRLYIRSE NKLHAMSIIS LCCADCLMGI
YLFVIGGFDL KFRGEYNKHA QLWMESTHCQ LVGSLAILST EVSVLLLTFL TLEKYICIVY
PFRCLRPGKS RTITVLILIW IIGFIVAFIP LSNKEFFKNY YGTNGVCFPL HSEHTESIGG
QIYSVAIFLG INLAAFIIII FSYASMFYSV HQSTITATEI RNQVKKEMIL AKRFFFIVFT
DALCWIPVFV LKFLSLLQVE IPGTITSWVV IFILPINSAL NPILYTLTTR PFKETIHQFW
YNYRRRRSMD SKVQKTYAPS FIWVEMWPLQ EMPPELMKPA VFTDPCEMSW ISQSTRLSSY
S
//
