ID F7IV43_TREPA Unreviewed; 364 AA.
AC F7IV43;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Octaprenyl-diphosphate synthase {ECO:0000313|EMBL:AAC65646.1};
GN OrderedLocusNames=TP_0683 {ECO:0000313|EMBL:AAC65646.1};
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=243276 {ECO:0000313|EMBL:AAC65646.1, ECO:0000313|Proteomes:UP000000811};
RN [1] {ECO:0000313|EMBL:AAC65646.1, ECO:0000313|Proteomes:UP000000811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols {ECO:0000313|EMBL:AAC65646.1,
RC ECO:0000313|Proteomes:UP000000811};
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.,
RA Gwinn M., Hickey E.K., Clayton R., Ketchum K.A., Sodergren E.,
RA Hardham J.M., McLeod M.P., Salzberg S., Peterson J., Khalak H.,
RA Richardson D., Howell J.K., Chidambaram M., Utterback T., McDonald L.,
RA Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S., Hatch B.,
RA Horst K., Roberts K., Watthey L., Weidman J., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|ARBA:ARBA00006706, ECO:0000256|RuleBase:RU004466}.
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DR EMBL; AE000520; AAC65646.1; -; Genomic_DNA.
DR PIR; C71295; C71295.
DR RefSeq; WP_010882128.1; NC_021490.2.
DR AlphaFoldDB; F7IV43; -.
DR STRING; 243276.TP_0683; -.
DR EnsemblBacteria; AAC65646; AAC65646; TP_0683.
DR GeneID; 57879208; -.
DR KEGG; tpa:TP_0683; -.
DR PATRIC; fig|243276.9.peg.675; -.
DR eggNOG; COG0142; Bacteria.
DR HOGENOM; CLU_014015_2_1_12; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001:SF69; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000000811};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
SQ SEQUENCE 364 AA; 40170 MW; EB3588FB570D6A69 CRC64;
MKRALAQRLR NIERALADAL PAQPTRSWMG TRLRVLASED TRVLRTVCNA CVSCGGKRWR
PLLLILSAEL AHACVQCTHR KLQGHKRKKI SEREWYTLSA VVELIHTASL LHDDIEDHSS
TRRGKPCAYL RYGTDCVLNA ASWLYFHAHA LIDTLSIEPA LKAALFSATI SATRALHMGQ
ALDIAWHRSP ELIPSRAQYL RMVALKTGAL IALSGELGFL CAGYSAREAR SFGAQVMPIG
IGFQILDDVQ GIDGGVSGKA HADDIVEGKK SFPVILHVHT HPQDAPTFAR LFAAARAEGL
HSPAVKQAQR ILYSSEALTH ARAYGLRMIE RTLTRVHAHF PCNPACQLWC TAVQYGVRAH
LHAH
//
