ID   F7JUN2_9FIRM            Unreviewed;       666 AA.
AC   F7JUN2;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGN49359.1};
GN   ORFNames=HMPREF0991_00845 {ECO:0000313|EMBL:EGN49359.1};
OS   Lachnospiraceae bacterium 2_1_58FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658082 {ECO:0000313|EMBL:EGN49359.1, ECO:0000313|Proteomes:UP000004820};
RN   [1] {ECO:0000313|EMBL:EGN49359.1, ECO:0000313|Proteomes:UP000004820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2_1_58FAA {ECO:0000313|EMBL:EGN49359.1,
RC   ECO:0000313|Proteomes:UP000004820};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA   Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA   MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGN49359.1}.
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DR   EMBL; ACTO01000014; EGN49359.1; -; Genomic_DNA.
DR   AlphaFoldDB; F7JUN2; -.
DR   PATRIC; fig|658082.3.peg.849; -.
DR   HOGENOM; CLU_000445_113_1_9; -.
DR   OrthoDB; 9806130at2; -.
DR   Proteomes; UP000004820; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd01987; USP_OKCHK; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR038318; KdpD_sf.
DR   InterPro; IPR025201; KdpD_TM.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR   InterPro; IPR006016; UspA.
DR   PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR   PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR   Pfam; PF13493; DUF4118; 1.
DR   Pfam; PF02702; KdpD; 1.
DR   Pfam; PF00582; Usp; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        404..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        434..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        455..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..503
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          28..236
FT                   /note="Signal transduction histidine kinase osmosensitive
FT                   K+ channel sensor N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02702"
FT   DOMAIN          256..372
FT                   /note="UspA"
FT                   /evidence="ECO:0000259|Pfam:PF00582"
FT   DOMAIN          412..515
FT                   /note="Sensor protein KdpD transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13493"
SQ   SEQUENCE   666 AA;  75744 MW;  FCB40729CB0E899C CRC64;
     MTEENRPDPG LLLKKLQYEE KEKEKQTKGK LKIFLGYAAG SGKTYAMLGA AHEAKKHQVD
     VVAGYIEPHA RPDTQAMAEG LEEIPPLMVD YKGIQLREFN LDAALERKPK LILVDELAHT
     NVRGSRNEKR YQDVRELLRA GINVYTTMNI QHLESLNDLV GNITNIEVKE RVPDSVFDQA
     DQVEVIDIEP EDLIERMKEG KIYGPVQAER ALENFFRREK LVALREIALR RSADRVNRIA
     EEERNILGNT GYHTGEHILA CISAAPSSAK VIRTAARLSY AFHAQFTALY VETPAMQEAG
     EKTKQTLKSH LELAKALGAK IVTVYGEDAA YQIAEYATVS NVSKVVMGRT NHRGIWRRPR
     IEVMEKLTHM APNIDVYIIP DIRKETHKRE VQIQRRRKTS WKNVFLDLAE ITGVMAVATL
     AAYVLWLFRL PESNIIMIYI LGILLSSYIA NKKIYALYSS LISVFAFNFL FTEPYFSLKA
     YDKGYPTTFV MLFLVGLFTA TLTRRLKQQS RESAKKAYRT EILLENSQKL RRCKSKQEVW
     TQVAGQAGKL LNLSLIIYPM EGSQMSDTPL LFPRKGMDML HLKTCINRQE LAVAQWVAAN
     HHRAGACTHT LPDAKAMYLP IQDARDVKGV MGILLEERRP IQEFEYGLLI AMLNETGVKL
     QDTFLE
//