ID   F7KKP2_9FIRM            Unreviewed;       552 AA.
AC   F7KKP2;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0000259|Pfam:PF00501};
GN   ORFNames=HMPREF0994_06421 {ECO:0000313|EMBL:EGN48029.1};
OS   Lachnospiraceae bacterium 3_1_57FAA_CT1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658086 {ECO:0000313|EMBL:EGN48029.1, ECO:0000313|Proteomes:UP000003336};
RN   [1] {ECO:0000313|Proteomes:UP000003336}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_57FAA_CT1 {ECO:0000313|Proteomes:UP000003336};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA   Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA   MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EGN48029.1, ECO:0000313|Proteomes:UP000003336}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_57FAA_CT1 {ECO:0000313|EMBL:EGN48029.1,
RC   ECO:0000313|Proteomes:UP000003336};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Allen-Vercoe E., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M.,
RA   Haas B., Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M.,
RA   Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA   McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGN48029.1}.
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DR   EMBL; ACTP02000009; EGN48029.1; -; Genomic_DNA.
DR   AlphaFoldDB; F7KKP2; -.
DR   STRING; 658086.HMPREF0994_06421; -.
DR   PATRIC; fig|658086.3.peg.7031; -.
DR   eggNOG; COG1022; Bacteria.
DR   HOGENOM; CLU_000022_59_9_9; -.
DR   Proteomes; UP000003336; Unassembled WGS sequence.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR43201:SF5; MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003336}.
FT   DOMAIN          25..408
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   552 AA;  61483 MW;  0E28BC9D1D718FBB CRC64;
     MKNFPRNDVT YYDTFDAFMD GIEKEFGDKT AVSWFLRNRT EESRSFRELA GEVGQLRGAI
     CGRGLAGKNI AIVGENSYAW IVTYLAVASC GGTAVCIDAE QSNESIWQMM QMAEVEAVFA
     SDVCLPICEE VPEGKERIQM FVLLGDAKED GVLTFSRLCE EGENYLAQNG PAVYPPIEAR
     QTAAIAFTSG TTSISKPVML SNQAILYNAS DSSVYVSAGE RVFTSLPFYH TYGMTCAVLA
     TLVRGAALII NGDLKTVMRD LHLSRAESML TVPLMIEAIH NQLWLNAERE GQEEGLRRLL
     RLQRVLRKMG IKTRIKVLED VRQKCVGTLR TIICGGAHLN KEIAEEFLML GILVLQGYGI
     TECSPLVSVN SNYSYDMDSV GHVLPHCEVK IENEEILVRG KNVMNGYYKS PELTAEVMQG
     EWFKTGDLGH LGRDGFLYIT GRKKNLIVFK NGKKISPEKL EEKIGMIPLV KDVLVYGAVS
     GASADDVKLA ASIYPDPERA KGLSSYEILE QLQEEINKIN SHLPFYQQVQ MVNIREQEFS
     KTASKKIKRH MV
//