ID   F7KQZ9_9FIRM            Unreviewed;       574 AA.
AC   F7KQZ9;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Peptidoglycan glycosyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF0993_01404 {ECO:0000313|EMBL:EGN39712.1};
OS   Lachnospiraceae bacterium 5_1_57FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=658085 {ECO:0000313|EMBL:EGN39712.1, ECO:0000313|Proteomes:UP000005617};
RN   [1] {ECO:0000313|EMBL:EGN39712.1, ECO:0000313|Proteomes:UP000005617}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5_1_57FAA {ECO:0000313|EMBL:EGN39712.1,
RC   ECO:0000313|Proteomes:UP000005617};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA   Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA   MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 5_1_57FAA.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGN39712.1}.
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DR   EMBL; ACTR01000010; EGN39712.1; -; Genomic_DNA.
DR   AlphaFoldDB; F7KQZ9; -.
DR   PATRIC; fig|658085.3.peg.1447; -.
DR   HOGENOM; CLU_009289_6_0_9; -.
DR   Proteomes; UP000005617; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005617};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..198
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          243..563
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   574 AA;  63417 MW;  3B4DF849C24EC8C2 CRC64;
     MKNKTYNKKK IFVVFICAAA IILALVGRLV YLMVFDAQYY QKKAEALHER EREIKAARGE
     IVDAGGTVLA TNKTVCTISV IHSQVKDPET VIRELSAALE MDETTVRARV EKVSSMERIK
     ANVDKATGDK IRNLELEGVK VDEDFKRYYP YNELASKVLG FTGGDNQGII GLEVKYEEYL
     KGINGTILTT TDARGVELDG VAEDRVEPVA GNTLQVSLDY NIQMYAQQMA EKVMEEKQAD
     KVAILLMNPQ NGEILAMVNV PEFNLNEPFT LNSGESGDSM TDEKKQEALN QMWRNGCIND
     TYEPGSTFKI ITASACLEEG VVHLDDTFSC PGYRVVEDRK IRCHKVGGHG SETFVQGIQN
     SCNPVFIDIG LRLGVDRFYD YFGQFGLMDM TGVDLPGEAG TIMHKKENIG LVELATMSFG
     QSFQITPMQM ATTVSSLING GRRVTPHFGV RVLDSKGKEI EEFRYKEKKN IVSEETSATM
     RMLLESVVSE GSGKNAKVEG FRIGGKTATS QTLPRSANKY ISSFIGFAPA DNPQVLGMCV
     IYNPQGVYYG GTIAAPVIGN IFENILPYLG IEKQ
//