ID F7NTF9_9GAMM Unreviewed; 730 AA.
AC F7NTF9;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN ORFNames=Rhein_1117 {ECO:0000313|EMBL:EGM78776.1};
OS Rheinheimera sp. A13L.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Chromatiaceae;
OC Rheinheimera.
OX NCBI_TaxID=506534 {ECO:0000313|EMBL:EGM78776.1, ECO:0000313|Proteomes:UP000004282};
RN [1] {ECO:0000313|EMBL:EGM78776.1, ECO:0000313|Proteomes:UP000004282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A13L {ECO:0000313|EMBL:EGM78776.1,
RC ECO:0000313|Proteomes:UP000004282};
RX PubMed=21742876; DOI=10.1128/JB.05636-11;
RA Gupta H.K., Gupta R.D., Singh A., Chauhan N.S., Sharma R.;
RT "Genome Sequence of Rheinheimera sp. Strain A13L, Isolated from Pangong
RT Lake, India.";
RL J. Bacteriol. 193:5873-5874(2011).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGM78776.1}.
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DR EMBL; AFHI01000008; EGM78776.1; -; Genomic_DNA.
DR RefSeq; WP_008898003.1; NZ_AFHI01000008.1.
DR AlphaFoldDB; F7NTF9; -.
DR STRING; 506534.Rhein_1117; -.
DR eggNOG; COG0317; Bacteria.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000004282; Unassembled WGS sequence.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
FT DOMAIN 401..462
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 656..730
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 730 AA; 82210 MW; 2E073B4028FA6923 CRC64;
MVTVRQSHSA EYHPGGTQSW LSALGLPEAK INALLDAELW LHQQNLTDQE PEVQTGWEMV
EILADLRMDK DALTAALLFP LVEAKLLDLE QVEAQFCPAV LTMLNAVRQM EAIRSIPVGP
NQSSNPQQAD NLRRMLLAMV EDVRAVVLKL AAQICYLRGV KNADEETRVL AAKETNAIFG
PLANRLGIGQ IKWELEDLAF RYLHPQTYKQ IASLLEEKRL DREQYMQDFV GSVRQKMQDA
AISVEVYGRP KHIFSIWKKM QKKQLAFDQL YDIRAVRIVT TKVQDCYAAL GIVHTSWRHL
PKEFDDYIAT PKQNGYQSIH TVVLGPAGRP VEIQIRTHQM HDDAELGVAA HWRYKEGAGH
AAKEGQLDEK ISWLRKLLAW QEELVDGSDL AEELKNQVTE DRVYVFTPKG DIVDLPVGST
PLDFAYYVHS NVGHRCIGAK ISGRIVPFTY QLKTGDQIEI LTGREPNPSR DWLNPNSGYL
KSSRARSKVQ YWFRLQDRDK NIAAGKDLLD TELNRLNLSI DSLPKVLARF NVNSMEELLA
GIGGGEIKVT QVVHYVQSQS GKLQQPEIDP RLISKPISTQ PKSHVVVQGV GNLLTHMAGC
CQPLPGDAIV GYITQGRGIA VHRDDCDQFK TLQEAHRERV VEATWGDKYA SGYEVTIRIV
AHDRNGLLRD ITSILANEKA NVLRMSSNSD ISQQTATIIM TMELYNLDSL NKLLTKVSQI
DDVIEAKRFH
//
