UniProt: F7PGR3

Database: UniProt
Entry: F7PGR3_9EURY

LinkDB:  F7PGR3_9EURY 
Original site:  F7PGR3_9EURY

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (12)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (2)   
Literature (3)   
   PubMed (3)   
All databases (25)   

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ID   F7PGR3_9EURY            Unreviewed;      1211 AA.
AC   F7PGR3;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HLRTI_001241 {ECO:0000313|EMBL:ERJ06686.1}, HTIA_1762
GN   {ECO:0000313|EMBL:CCQ33886.1};
OS   Halorhabdus tiamatea SARL4B.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Halorhabdus.
OX   NCBI_TaxID=1033806 {ECO:0000313|EMBL:ERJ06686.1, ECO:0000313|Proteomes:UP000003861};
RN   [1] {ECO:0000313|EMBL:ERJ06686.1, ECO:0000313|Proteomes:UP000003861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARL4B {ECO:0000313|EMBL:ERJ06686.1,
RC   ECO:0000313|Proteomes:UP000003861};
RX   PubMed=21705593; DOI=10.1128/JB.05462-11;
RA   Antunes A., Alam I., Bajic V.B., Stingl U.;
RT   "Genome sequence of Halorhabdus tiamatea, the first archaeon isolated from
RT   a deep-sea anoxic brine lake.";
RL   J. Bacteriol. 193:4553-4554(2011).
RN   [2] {ECO:0000313|EMBL:ERJ06686.1, ECO:0000313|Proteomes:UP000003861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARL4B {ECO:0000313|EMBL:ERJ06686.1,
RC   ECO:0000313|Proteomes:UP000003861};
RX   PubMed=24324765;
RA   Alam I., Antunes A., Kamau A.A., Ba Alawi W., Kalkatawi M., Stingl U.,
RA   Bajic V.B.;
RT   "INDIGO - INtegrated Data Warehouse of MIcrobial GenOmes with Examples from
RT   the Red Sea Extremophiles.";
RL   PLoS ONE 8:E82210-E82210(2013).
RN   [3] {ECO:0000313|EMBL:CCQ33886.1, ECO:0000313|Proteomes:UP000015381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARL4B {ECO:0000313|Proteomes:UP000015381}, and Type strain:
RC   SARL4B {ECO:0000313|EMBL:CCQ33886.1};
RX   PubMed=24428220; DOI=10.1111/1462-2920.12393;
RA   Werner J., Ferrer M., Michel G., Mann A.J., Huang S., Juarez S.,
RA   Ciordia S., Albar J.P., Alcaide M., La Cono V., Yakimov M.M., Antunes A.,
RA   Taborda M., Da Costa M.S., Amann R.I., Gloeckner F.O., Golyshina O.V.,
RA   Golyshin P.N., Teeling H.;
RT   "Halorhabdus tiamatea: proteogenomics and glycosidase activity measurements
RT   identify the first cultivated euryarchaeon from a deep-sea anoxic brine
RT   lake as potential polysaccharide degrader.";
RL   Environ. Microbiol. 16:2525-2537(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; HF571520; CCQ33886.1; -; Genomic_DNA.
DR   EMBL; AFNT02000011; ERJ06686.1; -; Genomic_DNA.
DR   RefSeq; WP_008524501.1; NZ_AFNT02000011.1.
DR   STRING; 1033806.HTIA_1762; -.
DR   GeneID; 23799680; -.
DR   KEGG; hti:HTIA_1762; -.
DR   PATRIC; fig|1033806.12.peg.1750; -.
DR   eggNOG; arCOG00802; Archaea.
DR   HOGENOM; CLU_001114_1_1_2; -.
DR   OrthoDB; 203178at2157; -.
DR   Proteomes; UP000003861; Unassembled WGS sequence.
DR   Proteomes; UP000015381; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          7..492
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          532..818
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         28..35
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1211 AA;  134598 MW;  7C4C7FE3C9D8A8C7 CRC64;
     MTEEPEEIQL TEEQEDALVQ GRNVAITAGA GTGKTTTLTE RYVTILAENP SLTPENIVTI
     TFTRKAAAEL TERVRAEVYD RLEAVDSPEA YHRWRNILDD LEDGYVHTIH AFCTRLLRER
     AVEAPVPLGF DVLDEDGAAT LQREVVTEFL ERNQDDDDVE LLAQLWSRDQ LVDVLAGLLD
     ERPQSESVLE AWRDAEIDDY VDICWEVVCD LDVADARQTL YADGLLEQLR TVAGRVDREE
     TIADADGLWA YQTFTEVATT LPEEPEDSDP RDCQRAILDL YEACEKKNGG LYSSSGYVVG
     DRDEWDEYGD VYDDLKDAID AVIAAVEPHA DTVETTPGEL EANSAHYALA LMRVFDDVLA
     AYADEKERRD TLDFPDVIET TLEFLRANDT VTERFQDQFA AVMVDEFQDT DPRQWELVKL
     LTGVDEQTAS NVFLVGDEKQ SIYGFRGADV TTFGAARAEL QAVNEARGVD NVPDREAESP
     TALELSGNFR TLDEPLSFLN ELFEYLFKPE GDIHEPYEAP PQELTTQRDR VEDIEGLTGS
     VEYLAVPDDA DMAAELFGDD HPVAEGALDH TIEAEAQALA ARLTHLFDDP PQVQDPDTEV
     HRDATPDDTA ILLRRRTHLD RYQRALEEYD IPYTVVGGVG FYDTPEVQAL TNLLRVLGDP
     QDDVSLYGVL RSPLFGFTDD RLAPAVAEAD SVWDALAETD YPQLADAFDL LTTWRTLSGC
     ATPSEDGVLP WNRLLSRVID DTGYLASVSA DERGQQAVAN VEKFRDQVRT WSENGVHTAA
     GLLHRIDRQA EIDPREGEAD IPGDAEGVRI MTIHSAKGLE FPIVTVPDLG SDLNFGRSVD
     DHGYVRLVEG TDNAPPLPAV GGPNPSDAFS IEKTAFHEYA DRQSLARERA ESKRLLYVAC
     TRTRDHLLLC GTHDIEVDES GAIELGEPAT FDNADRWRDW LQPALLDEVL VAEAIRDGQA
     RSELGGASYT VRSPPRPVDC HTDDATVDAA PEISISSPLT QASAKRIAAT TLVNAVADAS
     SGGHSYSQSE ETVGLSPTTF GTVVHRINEL RPPRDDWPKL IRRLSQMAGE EPTESDLRDA
     IDHAGDAVKF VDEVEADANL QAVYNEYSVI ARIGKSRIVG DIDRLLVTPN AFHIIDYKTN
     DLSSTTSDEL AEHYRPQMLA YALALLQHDQ NRDVRASLRF TDDGVEERFN WTSDQMSEIE
     SELRPMMDLV E
//

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