ID F7RXE5_9GAMM Unreviewed; 612 AA.
AC F7RXE5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Subtilisin-like serine protease {ECO:0000313|EMBL:EGN75311.1};
GN ORFNames=A28LD_0923 {ECO:0000313|EMBL:EGN75311.1};
OS Idiomarina sp. A28L.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Idiomarinaceae; Idiomarina.
OX NCBI_TaxID=1036674 {ECO:0000313|EMBL:EGN75311.1, ECO:0000313|Proteomes:UP000053031};
RN [1] {ECO:0000313|EMBL:EGN75311.1, ECO:0000313|Proteomes:UP000053031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A28L {ECO:0000313|EMBL:EGN75311.1,
RC ECO:0000313|Proteomes:UP000053031};
RX PubMed=21742887; DOI=10.1128/JB.05648-11;
RA Gupta H.K., Singh A., Sharma R.;
RT "Genome Sequence of Idiomarina sp. Strain A28L, Isolated from Pangong Lake,
RT India.";
RL J. Bacteriol. 193:5875-5876(2011).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN75311.1}.
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DR EMBL; AFPO01000012; EGN75311.1; -; Genomic_DNA.
DR AlphaFoldDB; F7RXE5; -.
DR STRING; 1036674.A28LD_0923; -.
DR MEROPS; S08.111; -.
DR PATRIC; fig|1036674.4.peg.914; -.
DR eggNOG; COG1404; Bacteria.
DR eggNOG; COG3291; Bacteria.
DR OrthoDB; 9790784at2; -.
DR Proteomes; UP000053031; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07477; Peptidases_S8_Subtilisin_subset; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR034202; Subtilisin_Carlsberg-like.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000053031};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..612
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003367748"
FT DOMAIN 129..309
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 342..419
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 428..492
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 134
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 167
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 444
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 612 AA; 61979 MW; E505B7CBBDD89D92 CRC64;
MTNKTKFKKS VLVAAIASVF ASPMLIAEVS ANDEQRVIVA FQPGAKAAVA QAVERAGGRK
EVELANDNAF AITVPAQAIR GLERNPNVLY IEEDVKRELF SSEFEPGQPY GIGMVQADQL
SAALAGNRKV CVIDSGYDLG HPDLQTTGVD GIFDSGTGNW FTDENGHGTH VTGTIAALAN
GVGVVGVVPN GQLNIHVVKV FAESGWAYSS NLIAAADQCA NYGSNVINMS LGGTFSSTTE
RNAFQRLNDN GVLSIAAAGN SGNTQLSYPA SYPAVVSVAA VDRDGNHASF SQRNSSVEIA
GPGVDVMSTV PRGTGSLALF SAGGATYSGL PMDGSPNGDV SGGLVDCGLG TSTCQGAQGN
ICLVERGQVS FADKVLACQN GGGVGAVIYN NEAGALSGTL GGVSVNIPAL GISQADGQTA
LASVGSSASV SVGASDWASF NGTSMASPHV AGVAALVWSY FTECTNDEIR AALNATAEDR
GTAGRDDLYG YGIVKAKDAY DYLATNGCAG GNGGDTGGGD DGGDTGGGDD GVASITLSAD
AYKARGRTSV DLSWSGAESS SVTIFRNGSS LAMVSNTGSY TDNTGLRGGG TLTYKVCEAG
TETCSDEVTI SY
//
