ID F7SUM6_9BURK Unreviewed; 884 AA.
AC F7SUM6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AXXA_01828 {ECO:0000313|EMBL:EGP48245.1};
OS Achromobacter insuavis AXX-A.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Achromobacter.
OX NCBI_TaxID=1003200 {ECO:0000313|EMBL:EGP48245.1, ECO:0000313|Proteomes:UP000004853};
RN [1] {ECO:0000313|EMBL:EGP48245.1, ECO:0000313|Proteomes:UP000004853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AXX-A {ECO:0000313|EMBL:EGP48245.1,
RC ECO:0000313|Proteomes:UP000004853};
RA Bador J., Amoureux L., Neuwirth C.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGP48245.1}.
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DR EMBL; AFRQ01000015; EGP48245.1; -; Genomic_DNA.
DR RefSeq; WP_006390420.1; NZ_GL982453.1.
DR AlphaFoldDB; F7SUM6; -.
DR PATRIC; fig|1003200.3.peg.351; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_1_4; -.
DR Proteomes; UP000004853; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 708..724
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 634..641
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 884 AA; 96132 MW; 577ABBAB6B556369 CRC64;
MNSATQTTAA EAHAGHTPMM QQYLRLKAEA GPLLLFYRMG DFYEMFYEDA ERGARLLNLT
LTKRGSSNGT PIPMAGLPVH AMEQYLARLV AMGESVAICE QIGDPAASKG PVERRIVRIV
TPGTLTDDAL LPAKADRALA AVFVSGNARA PRAGLAWLNL ASGDFRVTEC APAQLESELH
RVAPAEIVCA DSAEFDFPFE GARSRVPDWH FESDGARAHL LAHFKTDTLA GFDIEDMPAG
ICAAGALLRY AARTQSQALA HVQSLSAERP GQFVLLDPVT RRNLELTQTL SGEDSPTLFS
LLDGCRTPMG SRLLRRWLHH PLRENEQAHA RQQAISTLLA GRMDVEQTFG SAGLLETLRG
ALNAFPDIER IAARLALRSV RPRELASLRD ALQALPALRD LVAPMAASPR LNDLISHLSV
DPALAALLVR AIAAEPAVAI RDGGVLAAGF DAELDELRGL AADGGDFLVQ LEARERERTG
ISNLRVEFNR VHGFYIEVTK GQTAKVPEDY RRRQTLKNAE RYITPELKTW EDKVLSAQDR
SLAREKWLFE QLLDVLAEHV RPLSDCAGAL AELDTLAALA EHARRHDWIA PELSEQADID
IDAGRHPVVE QAIERFTPNG CRLDPARRML LITGPNMGGK STYMRQVALI VLLARIGSFV
PAARARIGRI DRIFTRIGAA DDLAGGRSTF MMEMTEAAAI LAASTPNSLV LMDEIGRGTS
TYDGLALAWA IACRLLAHNR ALTLFATHYF ELTRLPAEQP ASANVHLAAA ESAGGIVFLH
EVREGPASRS YGIQVAQRAG VPAAVIRQAT RELERLEAQG APTPQLGLFS AAADADAQAY
AEADRADAIE ALDTLREELA GIDPDSLTPR EALDALYRLK KHLQ
//
