ID F7V154_EEGSY Unreviewed; 593 AA.
AC F7V154;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Acyl-coenzyme A synthetase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=EGYY_13450 {ECO:0000313|EMBL:BAK44497.1};
OS Eggerthella sp. (strain YY7918).
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=502558 {ECO:0000313|EMBL:BAK44497.1, ECO:0000313|Proteomes:UP000008929};
RN [1] {ECO:0000313|EMBL:BAK44497.1, ECO:0000313|Proteomes:UP000008929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YY7918 {ECO:0000313|EMBL:BAK44497.1,
RC ECO:0000313|Proteomes:UP000008929};
RX PubMed=21914883;
RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT "Complete Genomic Sequence of the Equol-Producing Bacterium Eggerthella sp.
RT Strain YY7918, Isolated from Adult Human Intestine.";
RL J. Bacteriol. 193:5570-5571(2011).
RN [2] {ECO:0000313|Proteomes:UP000008929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YY7918 {ECO:0000313|Proteomes:UP000008929};
RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT "Complete genome sequence of the equol-producing bacterium Eggerthella sp.
RT strain YY7918 isolated from adult human intestine.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; AP012211; BAK44497.1; -; Genomic_DNA.
DR RefSeq; WP_013979747.1; NC_015738.1.
DR AlphaFoldDB; F7V154; -.
DR STRING; 502558.EGYY_13450; -.
DR KEGG; eyy:EGYY_13450; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_59_10_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000008929; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008929};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..444
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 495..573
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 593 AA; 65795 MW; 40D160B5E5C818E8 CRC64;
MRNINLRFVT ETYNEAGLLS DFAVNCPENF NFGYDVVDDI AVADPDRRAM VWCNPEGEEH
VFTFADMKKW SDKTANFLAE AGIGRGDMVM VILRRHYQFW FVATALAKLG AVMVPATFML
KEHDLEYRLN GASIKAIIAT SLGTIADVVD NVADECPTLE TRILVNGAGG GLTPEDENGN
LVFPDDGLPL GEMLSGPDGI CAAPAERAGW LDFNTGVRAA SADFTRRATA AADPMLMYFS
SGTSGNPKMV LHDSEYAIAH LVTAKHWHNV DPEGLHFTIA DTGWGKAVWG KYYGQWLMEA
CVFTYDFDRF HPSEILSLIG KYRITTLCCP PTMYRMMMAE DVDAYDLTLL VYSTTAGEAL
NPDLFDFWKE HTGLTIYEGF GQTETPLTIA NLTGSTPRPG SMGKPVPLYN VEIQRADGSR
CDTGETGEVC IDIHQKAAGI MLEYYRDPAK TEAAMYDGWY HTGDMAWCDE DGYFWYVGRN
DDVIKSSGYR IGPFEIESVL LEHEAVRECA VTGVPDPVRG KAVKATIVLT DGFTGSTELT
RELQTWVKKR TAPYKYPRIV EYVDELPKTV NGKIRRAAIR EVDEAEKAPE GLL
//
