ID F7WAE4_SORMK Unreviewed; 1164 AA.
AC F7WAE4;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=SMAC_08623 {ECO:0000313|EMBL:CCC14179.1};
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC14179.1, ECO:0000313|Proteomes:UP000001881};
RN [1] {ECO:0000313|EMBL:CCC14179.1, ECO:0000313|Proteomes:UP000001881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC {ECO:0000313|Proteomes:UP000001881};
RC TISSUE=Mycelium {ECO:0000313|EMBL:CCC14179.1};
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCC14179.1}.
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DR EMBL; CABT02000060; CCC14179.1; -; Genomic_DNA.
DR RefSeq; XP_003345672.1; XM_003345624.1.
DR AlphaFoldDB; F7WAE4; -.
DR STRING; 771870.F7WAE4; -.
DR GeneID; 10803027; -.
DR KEGG; smp:SMAC_08623; -.
DR VEuPathDB; FungiDB:SMAC_08623; -.
DR eggNOG; KOG2062; Eukaryota.
DR HOGENOM; CLU_002323_0_1_1; -.
DR InParanoid; F7WAE4; -.
DR OMA; IMFGRQE; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 3.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000001881};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..122
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 185..420
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 864..1044
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 358..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 125858 MW; 72839E00FCC97C87 CRC64;
MPGLVTATGV LAFLADEEPE LKVFALKTLN DDIDTVWTEV AGALTQIEAL YEDETFPERQ
LAALVLAKVY FHLQAYNESM TFALAAGPLF KLDAPSEFEE TIISKCIDQY IAVSSLHHTP
SKKDLPTLST DIGSGAIDSS ALISPTTPFS QSSVPSKSLL ARASSDDNTI LDPTFQPTKE
TRSASIAQVH DTATQVALQN IIERLFENCL KEGKYRQVVG IAVEAKNLDV LRRVIKRASE
DVKSGKTKVQ EGSQGPAEEL MDYALGICMD IVQERGFRTE ILRLILDLLN DIPNPDYFAI
AKCVVYLDSD EEASRMLRQL VTKGEQDSIA IAYQIAFDLY DNGTQEFLGK VIKALPSGEP
AKPKAESSDA AAESEPLLEG QESSEEELSE EVAKVYKNIR KILDGSKAIK LNLEFLYRNN
HTDMSILNKV RDSLDGRNSI FHSAVTFCNA FMNAGTTNDR FFRDNLEWLG RAVNWSKFTA
TAALGVLHRG NVTQSRKLLE PYLPRPSGVS TGSIYSQAGA LYAYGLIHAN HGADALAYLH
QQFKDADQEV IQHGGALGLG IAGMGTGDQR IIEDLKEALY SDSALNGEAV GAAMGLIMLG
TGHAPTIDAM FTYAHETQHE KIVRGIALGI ALIMFGQQES ADRTIQMLLA NPDPILRYGG
VLTLAMAYCG TGSNKAIRKL LHLAVSDVND DVRRVAVMSL GFILFRKPGS VPRMVELLAE
SYNPHVRYGS AMALGIACAG TGLDEAIDLL EPMMKDPTDF VRQGALIALA MILVQQNEVM
NPKVAAIRKT LKKVVSDRHE EQMTKFGASL ALGIIDAGGR NCTIGLQTQT GNLNMAGIVG
MAVFTQYWYW FPFTHFLSLS FVPTSIIALD SDLAIPNTKF HCATRPSLFD YPPEQEVKVE
EGPALVTTAV LSTTAQAKRR AQKKEKAQRR ESMDIDTPAV AKTTQAAAAE DKMDIDEDKK
VVAKPEESKE KKEGEDKETT AATEAKKKAE KEKVGYEIDN MSRILPGQLK YISFPAGRYK
PVKKPTGGPL LLFDTQPSEA KSLVEEKLNK VTTERAPVAG ASASGSNDGT PRLNTSAAQS
LLSQLQGTGL STGLREVDAG AGAGFEERTA AASSGRGAAA GSGAGAAAAA AVLMAVDEDG
EGDEEAQTPA EFEYFTDAEA DDEE
//
