ID   F7Y0H7_MESOW            Unreviewed;      1159 AA.
AC   F7Y0H7;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Pyruvate/ketoisovalerate oxidoreductase {ECO:0000313|EMBL:AEH84815.1};
GN   OrderedLocusNames=Mesop_0320 {ECO:0000313|EMBL:AEH84815.1};
OS   Mesorhizobium opportunistum (strain LMG 24607 / HAMBI 3007 / WSM2075).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=536019 {ECO:0000313|EMBL:AEH84815.1, ECO:0000313|Proteomes:UP000001623};
RN   [1] {ECO:0000313|EMBL:AEH84815.1, ECO:0000313|Proteomes:UP000001623}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 24607 / HAMBI 3007 / WSM2075
RC   {ECO:0000313|Proteomes:UP000001623};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Misra M., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Mavrommatis K.M., Tiwari R.P.,
RA   Howieson J.G., O'Hara G.W., Nandasena K.G., Woyke T.;
RT   "Complete sequence of Mesorhizobium opportunistum WSM2075.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002279; AEH84815.1; -; Genomic_DNA.
DR   RefSeq; WP_013891563.1; NC_015675.1.
DR   AlphaFoldDB; F7Y0H7; -.
DR   STRING; 536019.Mesop_0320; -.
DR   KEGG; mop:Mesop_0320; -.
DR   eggNOG; COG1014; Bacteria.
DR   eggNOG; COG4231; Bacteria.
DR   HOGENOM; CLU_009166_1_0_5; -.
DR   Proteomes; UP000001623; Chromosome.
DR   GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR   CDD; cd02008; TPP_IOR_alpha; 1.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   InterPro; IPR046667; DUF6537.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   PANTHER; PTHR48084:SF4; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB; 1.
DR   PANTHER; PTHR48084; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED; 1.
DR   Pfam; PF20169; DUF6537; 1.
DR   Pfam; PF01558; POR; 1.
DR   SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:AEH84815.1}.
FT   DOMAIN          725..912
FT                   /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01558"
FT   DOMAIN          941..1139
FT                   /note="DUF6537"
FT                   /evidence="ECO:0000259|Pfam:PF20169"
SQ   SEQUENCE   1159 AA;  124961 MW;  647BD26AE34A785D CRC64;
     MTLHDVALDD KFDLGKERIF LSGAQAVIRM LLMQRERDRR AGLNTAGFVS GYRGSPLGGL
     DMQLWKAKKQ LAGADIVFQP GLNEELAATA CWGSQQTELL GEGTHDGVFS VWYGKGPGVD
     RSGDVFRHAN LAGSSKHGGV LALMGDDHMA ESSTNAHATE FLFVDTMVPI LNPAGVQEII
     DYGLYGFAMS RFAGTWAAIK CVKDNIESTA SVDASLERLN IVVPEFDMPP GGLNIRHEID
     MLGQEERLHE HKRAAASAFI HANGLNRIVY SGGRSPKIGI ITLGKSYLDV RQALEDIGID
     EAAANRIGVR LFKVGCPWPL DLHHIADFAR GLDTIVVVEE KRSLIEVQLR ESLYGTASQP
     VIVGKKDERG DWLFPAKGAL DPNEIAIALG EKIVKTIGPS EEISARVGKL RQFQAMLADA
     TDIGSRTPFF CSGCPHNSST KVPDGSIAAA GIGCHFMALW MDRNTLGFTA MGGEGAQWVG
     QAPFSKRDHI FQNLGDGTYN HSGTLAIRFA LSSEANITYK ILYNDAVAMT GGQPHEGGLT
     VEMIARQVRA EGVDRIAIVT DEPDKYAGKV EFPAGASIHH RDDLDLVQRE LRDVKGVSIL
     IYDQTCAAEK RRRRKRGTFP DPDKRVFINE LVCEGCGDCG VQSNCVSIQP VETEFGRKRK
     IDQSSCNKDF SCINGFCPSF VTVHGAKIRK AEGLAGKADP LDGVPTPAEF PLGAEGWAAI
     IDGVGGTGVV TVGAVLGMAA HLEDKGCGMI DMAGLAQKGG SVFTHVRIAR TPDDIHAIRV
     SAGKADLVLG CDLVVSGAKK VLTAVREGHT IFLANTAEIM PGEFARSADF SLPIERLKKA
     IRSAAGDDKA HFFDATRTAT ALFGNSLGAN MFMLGFAFQH GGLPLSAEAV ERAIELNGEA
     VAMNIAAFRW GRRAAHQPDF VRGLVAQPGK AGQAAPVAQT LDEIIGRRVA FLTAYQNAAY
     GKRYADSLAR LRAAETKAVP GSTAVTEAAA RNLFKLMAIK DEYEVARLYT DGSFAAELGK
     QFQSYEKLEF HLAPPIMGRR GNDGKPRKSS FGPWMMKGFR LLAALKGLRG TAFDLFGYTG
     ERRMERQLLA QYEGDLELVA KSLAPGKIEA ATALMSVPAL IRGYGHVRQA SAEKAAGERQ
     RLLERLSAAS KRPELQAAE
//