UniProt: F7ZKF2

Database: UniProt
Entry: F7ZKF2_ROSLO

LinkDB:  F7ZKF2_ROSLO 
Original site:  F7ZKF2_ROSLO

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (17)   
   InterPro (8)   
   Pfam (4)   
   PROSITE (3)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (26)   

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ID   F7ZKF2_ROSLO            Unreviewed;      1867 AA.
AC   F7ZKF2;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=RLO149_c032100 {ECO:0000313|EMBL:AEI95166.1};
OS   Roseobacter litoralis (strain ATCC 49566 / DSM 6996 / JCM 21268 / NBRC
OS   15278 / OCh 149).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseobacter.
OX   NCBI_TaxID=391595 {ECO:0000313|EMBL:AEI95166.1, ECO:0000313|Proteomes:UP000001353};
RN   [1] {ECO:0000313|EMBL:AEI95166.1, ECO:0000313|Proteomes:UP000001353}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149
RC   {ECO:0000313|Proteomes:UP000001353};
RX   PubMed=21693016; DOI=10.1186/1471-2164-12-324;
RA   Kalhoefer D., Thole S., Voget S., Lehmann R., Liesegang H., Wollher A.,
RA   Daniel R., Simon M., Brinkhoff T.;
RT   "Comparative genome analysis and genome-guided physiological analysis of
RT   Roseobacter litoralis.";
RL   BMC Genomics 12:324-324(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP002623; AEI95166.1; -; Genomic_DNA.
DR   STRING; 391595.RLO149_c032100; -.
DR   KEGG; rli:RLO149_c032100; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG0514; Bacteria.
DR   HOGENOM; CLU_002862_0_0_5; -.
DR   Proteomes; UP000001353; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   CDD; cd18018; DEXHc_RecQ4-like; 1.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   NCBIfam; TIGR00614; recQ_fam; 1.
DR   PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          306..483
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          509..663
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          1090..1304
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          1700..1737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1844..1867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1709..1727
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1844..1860
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1111..1118
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1867 AA;  207403 MW;  C0227B16253FFFCE CRC64;
     MNDGHSKFLA RCLSIDLEVD PSTAKIFAMA AVWHDDRPAL VARKGVQDHH INQLEEAIAD
     IAHPIGHNIL HHDMEYLIAV KPRVSKLMQS PIDTLWLNPL AFPRNPYHRL VKHYHDGRLA
     VGHVNDPELD AQLVFKVLEN QLDAFLTLNS TDKDALTAYH YLTTRMERAS GFDAVFKYVR
     QADCPSEDDA LKAIRRMLSG RVCQKRMEQA LGRLASPHNG WPMAYALSWI TVAGGDSVMP
     PWVRAQFREA SLIVRHLRDT SCKDPGCDWC AEQNDPVRAL NKWFGFDSFR PQPVDPDGRP
     LQERIVDEAM SGISVLGILP TGTGKSVCYQ VPALSRFDKI GALTVVISPL VALMADQVQG
     MERAGISCSV TVNGMMSMPE RQDALDKVRM GDAGILIISP EQLRSTSIRS ALNQREVGLW
     AIDEAHCVSK WGHDFRPDYR YLGRFIKEHS GDQPPAPIIC LTATAKPEVV ADIMAHFQSR
     AGVELLPLDG GVSRTNLTFE VRPTTKSSKL SDVLTVIEEG IPSDGRSGAV VYCASRKETE
     RVADFLKSQG MDAAHFHAGL SPDDKQVVQE RFRVGDLRVI AATNAFGMGI DKPDIRLVVH
     ADIPGSLENY LQEAGRAGRD RADASCVLLF AADDVERQFR LTASSRLARH EIGAILKALR
     RIDEKTNKTG KIVATAGEIV RSEKDREFER DSTTDDTRVK TAVSWLEEAT LVSREENRVR
     ILPSSLRVRT FEEAKKRLAD ADITTAHRNQ LLGIVKHLMA APPDEGVSTD VLCGLSGLSS
     GALPKAMADL ETLGIASNDV AMTAFVHVGV SNPSSARLSE ASTLERDLIT LMQEMAPEAD
     DKTPYPLNLA ETCQNLRDNG HSTVRPNVVD KLLRGISRDG KGQDGGKGNI RLRKVSRNTL
     RLTVERSWKI ITQTAELRWA AASLLLNHLT GRLDKGARGK DLQVETTIGN LLAELTQDAF
     LKTSGVRDMT KLMERSLLWL HEQGVVTLGK GLTVFRPAMT VFLNPKGGQF TQADFLPLEE
     HYDEQTLQTH VMATYAETGL KSMVDATRLS EDYFLLNKEQ FMKRWMPGMG REIKRQTTSR
     SWKTIVEDLK NKVQQDIVTD DRDRTNVLVL AGPGSGKTRV LVHRIAYLLR MKREDSRGIL
     VLAYNRHAAA EIRVRLRALV GDDAAGVTIS TCHSLAMRLV GASFSGIDAD TTDFDNIITE
     AVGQLNGNGL SRSEAEAQRD SLIEGYRWIL VDEYQDIGPE EYALISAVAG RSLEDADLKL
     SLFAVGDDDQ NIYAFNGASI DFIRMFEEDY KARPAFLIEN YRSTANIIEA ANAVISKAPD
     RMKVDHEIRI NEARSLGVPG GRLADADPVA QGRVQLLDVP GGDTHQAIAA VDEMIRLSHL
     DPNWNWARTA IISRDWKRLG PVRTYAETKG LNVEMANEDL PNIWRLRETQ TLITGLRNTR
     GALLGVQDIL GILNEQDRNK WVDLLAEGIA ELARDLGTKA MPAPDIIEWV ADWSKDTLGE
     QRGLLLLTAH RAKGLEFDHV AIFNGGWDRA SRNEDREAPR RLFYVAMTRA QQSLTVLTSG
     EHALLKRGLN SVLHRPVVPD LPRSSPISKI YQMPKLDVVD LSFAGRKHDG HAIFSAINQA
     KVGDPLSLEY RAPYWMLVDK NNRLLGHMAK AWQPPEHHAF VSGHVGAIIT WRKTDNQESY
     RQHIRRDTWE TVLPELIFQP ERGQRTPDLT SRELTNEQGT QPVETSGPVS AGDRAEKVRK
     VKVTGHEAAK SPSLDDLQAI LKDAVSSTTT WEQLIGELEK HLITLSPKGG GLIVANMATG
     EQLCKLSALG LRYRKLIRHF GDGFPDHPME WLVERALKDS TVAKAPRKAR ARKKPAADDD
     DFDLIED
//

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