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Database: UniProt
Entry: F8B073_FRADG
LinkDB: F8B073_FRADG
Original site: F8B073_FRADG 
ID   F8B073_FRADG            Unreviewed;       500 AA.
AC   F8B073;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   05-JUL-2017, entry version 48.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=FsymDg_0006 {ECO:0000313|EMBL:AEH07599.1};
OS   Frankia symbiont subsp. Datisca glomerata.
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=656024 {ECO:0000313|EMBL:AEH07599.1, ECO:0000313|Proteomes:UP000001549};
RN   [1] {ECO:0000313|EMBL:AEH07599.1, ECO:0000313|Proteomes:UP000001549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4085684 {ECO:0000313|EMBL:AEH07599.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Chertkov O., Teshima H., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Berry A.,
RA   Pawlowski K., Persson T., Vanden Heuvel B., Benson D., Woyke T.;
RT   "Complete sequence of chromosome of Frankia symbiont of Datisca
RT   glomerata.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002801; AEH07599.1; -; Genomic_DNA.
DR   RefSeq; WP_013871597.1; NC_015656.1.
DR   ProteinModelPortal; F8B073; -.
DR   STRING; 656024.FsymDg_0006; -.
DR   EnsemblBacteria; AEH07599; AEH07599; FsymDg_0006.
DR   KEGG; fsy:FsymDg_0006; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; ATHIERN; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001549; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001549};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001549}.
FT   DOMAIN      191    319       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      403    472       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     199    206       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   500 AA;  55387 MW;  09C018BFC3A3B973 CRC64;
     MTDLSADPSA GMSGRVPVEE PDLSAVWGQA VAGVADGTLS AQQRAWLRLT RPLGLVQDTA
     LLAAPNEFTK DLLDSRLRPF LSTALSTAYG REIRVAVTVE HLPDPEPMTG PIQLPLPTSP
     VSPVSATPAV SAASAADTAR ITPGLGRDPA PRSYEPTRLN PRYVFETFVI GDSNRFPHAA
     AVAVAEAPAK AYNPLFIYGD SGLGKTHLLH AIGHYTLKLY PESRVKYVSS EEFTNDFINS
     IRDDRQQAFQ RRYRDTDVLL VDDIQFLENK ERTQEEFFHT FNVLHDTEKQ IVISSDRSPK
     QLSALEDRLR SRFEWGLITD VTPPDLETRI AILSKKAATE RLPVPGDVLE YIATHIERNI
     RELEGALIRV AAFASLNKSH VDRTLAEIVL RDLIPDAADP EITAAAIMNA TATYFGVSME
     DLCGTSRSRV LVTARQIAMY LCRELTDLSL PKIGQHFGGR DHTTVMHADR KIRGLMAERR
     AIYNQVTELT NRIRAQTRQA
//
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