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Database: UniProt
Entry: F8C307_THEGP
LinkDB: F8C307_THEGP
Original site: F8C307_THEGP 
ID   F8C307_THEGP            Unreviewed;       456 AA.
AC   F8C307;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   25-OCT-2017, entry version 47.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   OrderedLocusNames=TOPB45_1417 {ECO:0000313|EMBL:AEH23498.1};
OS   Thermodesulfobacterium geofontis (strain OPF15).
OC   Bacteria; Thermodesulfobacteria; Thermodesulfobacteriales;
OC   Thermodesulfobacteriaceae; Thermodesulfobacterium.
OX   NCBI_TaxID=795359 {ECO:0000313|EMBL:AEH23498.1, ECO:0000313|Proteomes:UP000006583};
RN   [1] {ECO:0000313|Proteomes:UP000006583}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OPB45 {ECO:0000313|Proteomes:UP000006583};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Davenport K., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA   Hamilton-Brehm S., Elkins J., Woyke T.;
RT   "Complete sequence of Thermodesulfobacterium sp. OPB45.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP002829; AEH23498.1; -; Genomic_DNA.
DR   RefSeq; WP_013910196.1; NC_015682.1.
DR   STRING; 795359.TOPB45_1417; -.
DR   EnsemblBacteria; AEH23498; AEH23498; TOPB45_1417.
DR   KEGG; top:TOPB45_1417; -.
DR   PATRIC; fig|795359.3.peg.1438; -.
DR   eggNOG; ENOG4105DVS; Bacteria.
DR   eggNOG; COG1570; LUCA.
DR   KO; K03601; -.
DR   OMA; NARRRWP; -.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000006583; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006583};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:AEH23498.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006583}.
FT   DOMAIN       19    112       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      134    448       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   456 AA;  53378 MW;  A27716FE9CB815F0 CRC64;
     MNELEEVKVD IEEREKLYFT VKEVTQELKT FIEAKFPLLW IEGEVANLRY AHNGNIYFNL
     IEEEASLKAI IFSYQKDIEI TPYLKNGLKV LCFGKLSFYP RSGECYFIVR RVEPLGKGLL
     TLKKEELIRK YQPLFDPNRK RAIPLYPKKI ALITSIFGAA LQDFLKVSKD RWELEILIYP
     VRVQGEGAEK EIVQAIKDIN NCFSDVEVII ITRGGGSFED LAPFYTEDII LGIKDSKIPV
     VSAVGHEIDY TICDLIADRR CATPTAAAEE IIPSKEDILH KLKLYKEKLD QLLEVIFTKK
     EKSLYEVKIE LENKNPFKII HHLERKIKDY YHKLVLETEK YFSLKEKKLW EIKNLLKKRH
     PQENIKFGEE RLKFFKNRLF YSIKVYFIEK EKKLENLKKL LISLSPLNIL QRGYSIVKSY
     PEGKIIKNAK EVKEGKLLEV YLSEGKLLVE VKKVEE
//
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