ID F8CFH0_MYXFH Unreviewed; 664 AA.
AC F8CFH0;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Acetyl-CoA carboxylase biotin carboxylase subunit {ECO:0000313|EMBL:AEI63580.1};
GN OrderedLocusNames=LILAB_08345 {ECO:0000313|EMBL:AEI63580.1};
OS Myxococcus fulvus (strain ATCC BAA-855 / HW-1).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=483219 {ECO:0000313|EMBL:AEI63580.1, ECO:0000313|Proteomes:UP000000488};
RN [1] {ECO:0000313|EMBL:AEI63580.1, ECO:0000313|Proteomes:UP000000488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-855 / HW-1 {ECO:0000313|Proteomes:UP000000488};
RX PubMed=21868801; DOI=10.1128/JB.05516-11;
RA Li Z.F., Li X., Liu H., Liu X., Han K., Wu Z.H., Hu W., Li F.F., Li Y.Z.;
RT "Genome sequence of the halotolerant marine bacterium Myxococcus fulvus HW-
RT 1.";
RL J. Bacteriol. 193:5015-5016(2011).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; CP002830; AEI63580.1; -; Genomic_DNA.
DR AlphaFoldDB; F8CFH0; -.
DR STRING; 483219.LILAB_08345; -.
DR KEGG; mfu:LILAB_08345; -.
DR eggNOG; COG4770; Bacteria.
DR HOGENOM; CLU_000395_3_1_7; -.
DR Proteomes; UP000000488; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 3..448
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 122..319
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 583..659
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 664 AA; 71037 MW; 5EF412EF2CE07FBD CRC64;
MERFKKVLIA NRGEIAVRVI RTCQRLGYRT VAVFSEADRA APHVLAADEA VAIGPSPAKE
SYLVIGKILE AAKASGAEAI HPGYGFLSEN ADFARACRDA GLVFIGPEAE AITLMGNKRQ
AKLRMIAADV PCIPGYEASD LDDEALAVEG ERIGFPLMVK AAAGGGGRGM RLVHEAAQLR
EALRAARSEA TNAFGSGELI LEKAVIDARH VEVQVFADAH GNVVHLGERD CSVQRRHQKI
VEESPSPAVS PALRARMGEV AVAAARAIGY RGAGTIEFLL APSGDFYFME MNTRLQVEHP
VTELITGLDL VEWQLRVAAG ERLPRAQAEV SASGHAIEVR LCAEDPAKGY APQAGRLLTW
TLPAREGVRI DHGVREGQEI PPFYDSMQAK VIAHGPDRET ARRRLVEALR ELTVFGVTTN
KNLLLYVLEH AAFRSGEYDT AFIAKHAPAS EVEGLYQADA RARALAAAAL FHDEGLKLAD
TAGLDASLVN WNTAHRHPVR MKLANRGAEE DVTVQPVSPE AYTVTVGDAS FDVSVLRLSG
GVLDFSSGGT RGRARYLRDG DTLWLDSGSG AHAVTDVTFR PPSKSDGVGS GRLAAPMDGR
ILRVDTRVGA AVKPGDVLLV LEAMKMEFQV VADVTGTVAE LNVSVGSQVR AKQLLVALAA
EKTA
//
