ID F8CRP5_MYXFH Unreviewed; 748 AA.
AC F8CRP5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Sensor protein ZraS {ECO:0000256|ARBA:ARBA00039705};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=LILAB_24490 {ECO:0000313|EMBL:AEI66793.1};
OS Myxococcus fulvus (strain ATCC BAA-855 / HW-1).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=483219 {ECO:0000313|EMBL:AEI66793.1, ECO:0000313|Proteomes:UP000000488};
RN [1] {ECO:0000313|EMBL:AEI66793.1, ECO:0000313|Proteomes:UP000000488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-855 / HW-1 {ECO:0000313|Proteomes:UP000000488};
RX PubMed=21868801; DOI=10.1128/JB.05516-11;
RA Li Z.F., Li X., Liu H., Liu X., Han K., Wu Z.H., Hu W., Li F.F., Li Y.Z.;
RT "Genome sequence of the halotolerant marine bacterium Myxococcus fulvus HW-
RT 1.";
RL J. Bacteriol. 193:5015-5016(2011).
CC -!- FUNCTION: Member of the two-component regulatory system ZraS/ZraR. May
CC function as a membrane-associated protein kinase that phosphorylates
CC ZraR in response to high concentrations of zinc or lead in the medium.
CC {ECO:0000256|ARBA:ARBA00037481}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
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DR EMBL; CP002830; AEI66793.1; -; Genomic_DNA.
DR AlphaFoldDB; F8CRP5; -.
DR STRING; 483219.LILAB_24490; -.
DR KEGG; mfu:LILAB_24490; -.
DR eggNOG; COG3852; Bacteria.
DR HOGENOM; CLU_375920_0_0_7; -.
DR Proteomes; UP000000488; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF54; SENSOR PROTEIN ZRAS; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AEI66793.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000313|EMBL:AEI66793.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 478..694
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 695..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82098 MW; 4E587E2CFBA973AB CRC64;
MDIRTQSALL ASIIGLALGV SMLLRPGRPR VLTLYSVFAL TVAGYYLSLF FHNVFPAADY
PWASRISVGA TILVASLVPG AAVAFFLEFL GVSKGTHLVG RRLALLSAVL GLTVAVTPLA
DKLWARVCMG VWVLGTLLTY GSLLLHRVRT TESRIEKFRL AYLAIGAGAA ILFSALDFLV
SFGIPFPTLG SVFSTLYLFF LAHTLLRLRL MDLHELLGKI ASQTVLASIL AAVFTVLTAW
GKENTGLFLF NTVVAAFVIL ILLEPLKVKV EEMVVRIFFR ERFALLDSLG SLRARMANVI
EISELARLVL DTLHETGRVT HASVYLLAED RPGYRLLDSR GPLPVAFLDT AVARGLLFAA
ASGQKAVLRE NVERRMATMR LQVVEGKRYR DELKRLNDTR AALVQVKAGI TVPLMGNDRV
IGFLNLWDER VPEAFASDEI AIILEVAERL ATVLENSKLY EKIRERDRLA ALGEMAAGLA
HEIRNPLGAI KGAAQCLDPA QFQGEDAEFL EVIVEEVNRL NGVVTAFLDY ARPMKQSFGT
TDLNEVVTRT MRLIQNDVPS NLQLAVELDL MLPRVDGDAE QLKQVLINLV QNAVQALGSR
EGRISVRTEK PERFGELRSA GAEFVEVQVS DNGPGIPPDQ HPHIFVPFYT TKQKGTGLGL
AICQRIVKNH GGSISVQSKV GEGSTFVIRL PALPTEQPPA SEAPFVEGLP AGTRPSQSLP
MPDELRDGAR PAQREPRAKR ERRKRLRA
//
