ID F8GP64_CUPNN Unreviewed; 693 AA.
AC F8GP64;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA1 {ECO:0000313|EMBL:AEI79226.1};
GN Synonyms=flhA {ECO:0000256|RuleBase:RU364093};
GN OrderedLocusNames=CNE_2c02400 {ECO:0000313|EMBL:AEI79226.1};
OS Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453
OS / N-1) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI79226.1, ECO:0000313|Proteomes:UP000006798};
RN [1] {ECO:0000313|EMBL:AEI79226.1, ECO:0000313|Proteomes:UP000006798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1
RC {ECO:0000313|Proteomes:UP000006798};
RX PubMed=21742890; DOI=10.1128/JB.05660-11;
RA Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT "Complete genome sequence of the type strain Cupriavidus necator N-1.";
RL J. Bacteriol. 193:5017-5017(2011).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
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DR EMBL; CP002878; AEI79226.1; -; Genomic_DNA.
DR RefSeq; WP_013951949.1; NC_015723.1.
DR AlphaFoldDB; F8GP64; -.
DR KEGG; cnc:CNE_2c02400; -.
DR HOGENOM; CLU_015346_3_0_4; -.
DR Proteomes; UP000006798; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:AEI79226.1};
KW Cilium {ECO:0000313|EMBL:AEI79226.1};
KW Flagellum {ECO:0000313|EMBL:AEI79226.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 117..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 210..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 291..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 693 AA; 74575 MW; AB00DE08F9A037D1 CRC64;
MNALSNLFNL PGLRSAGQLK AMTGPLLIIM ILGMMILPLP AFVLDLLFTF NIALAIMVLL
VSMYTQKPLD FAAFPAVLLF TTLLRLSLNV ASTRVVLLEG HTGPDAAGKV VEAFGHFLVG
GNFAVGIVVF AILVVINFMV ITKGAGRIAE VGARFMLDSM PGKQMSIDAD LNAGLIDEAA
AKKRRAEVAQ ESDFYGAMDG ASKFVRGDAV AGLLIMFINV AAGMVVGMVQ HDLDFGTAVH
NYTLLTIGDG LVAQIPALVI STAAGVIVSR VSNEQDVGEQ LTGQLFANPR VLYLTAGIIG
LMGIIPGMPH FAFLLLAGVL VWMGRYMSRR AATQEQVKQR EERTPAVAQE STEASWDDVT
LVDPLGMEVG YRLITLVDRA QDGELLGRIK SIRKKVAQEI GFLVPVVHIR DNLELKPNAY
RITLKGVEIG RGEAMPGQWM AINPGQVSGT LPGAATRDPA FGLPAVWIDA GIKEQAQSYG
YTVVDASTVV ATHLNHLIHM HAAELLGRQE VQALLDRIAK DSPKLTEDLV PKAISLTALQ
KILQNLLDEG VPIRDMRTIL DVVAEHAPKI SDPNELTAMV RVALGRAITQ QLFPNNADLQ
VIGLDAGLER VLSQALTNGG GIEPGLADAL LQQTQGAVTR QEQMGMDPVL LVPSQLRPLM
ARFLRRTMPQ LRVLSHAEVP DNRNIRITAM IGA
//
