ID F8GSG7_CUPNN Unreviewed; 731 AA.
AC F8GSG7;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Indolepyruvate oxidoreductase subunit IorA {ECO:0000313|EMBL:AEI81025.1};
DE EC=1.2.7.8 {ECO:0000313|EMBL:AEI81025.1};
GN Name=iorA2 {ECO:0000313|EMBL:AEI81025.1};
GN OrderedLocusNames=CNE_2c20760 {ECO:0000313|EMBL:AEI81025.1};
OS Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453
OS / N-1) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI81025.1, ECO:0000313|Proteomes:UP000006798};
RN [1] {ECO:0000313|EMBL:AEI81025.1, ECO:0000313|Proteomes:UP000006798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1
RC {ECO:0000313|Proteomes:UP000006798};
RX PubMed=21742890; DOI=10.1128/JB.05660-11;
RA Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT "Complete genome sequence of the type strain Cupriavidus necator N-1.";
RL J. Bacteriol. 193:5017-5017(2011).
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DR EMBL; CP002878; AEI81025.1; -; Genomic_DNA.
DR RefSeq; WP_013953702.1; NC_015723.1.
DR AlphaFoldDB; F8GSG7; -.
DR KEGG; cnc:CNE_2c20760; -.
DR HOGENOM; CLU_017727_0_0_4; -.
DR Proteomes; UP000006798; Chromosome 2.
DR GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02008; TPP_IOR_alpha; 1.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR045025; HACL1-like.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR PANTHER; PTHR43710:SF5; INDOLEPYRUVATE FERREDOXIN OXIDOREDUCTASE ALPHA SUBUNIT; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:AEI81025.1};
KW Pyruvate {ECO:0000313|EMBL:AEI81025.1}.
FT DOMAIN 627..658
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 731 AA; 78748 MW; 9E419320A0C8CA78 CRC64;
MAERSFAEEV KKLRLGSGEV FSGEGILAVT KALLESGVAY VAGYQGSPIS HLMDVLADAQ
DILAEHGIRF ENSASEATAA ASLAASVNYP LRGAVTFKAT VGTNVASDAL ANLASGGVTG
GALIIVGEDY GEGSSIMQER SHAFAMKSQM WLLDPRPNLP CIVQAVKDGF DLSEASNTPV
MLQLRVRSCH VHGQFVASDN RRSKFSIQDA LENPTRDLSR IVLPPASFVH EHEKIKQRWP
AAVKFIEERQ LNEFFQGEMD DIGIAVQGGS YNTLIRALEQ LGLADVFGES KIPLYVMNVA
YPLIDSEWER FCAGKRAVLV LEEGQPNFIE QNAANILRMA GTTATLHGKD LLPLAGEYNT
ATVHKGLRAF LEQYGKIEPL PEPKPARKVI PLVQAPAATV DAVAAEVLEP QKLVDESVHA
RPPGFCTGCP ERPIFTAMKL VEREIGEHHV SADIGCHLFS ILPPFNLGNT TMGYGLGSAS
AAALNAPGGK RAISVMGDGG FWHNGLTSGI ANAVFNKSDN LTIVVDNSYT SATGGQDILS
STALNDTRST GHAIEDAVKG VGVKWVRTIR RTYDLKAMKA TLKEALTTGA KGPKVLIAQS
ECMLNKQRRE KPKTRKAIAD GQRVVRERFG VDSDTCTGDH SCIRLSGCPS LTIKPNPDPL
RTDPVASVLD SCVGCGLCGE VSHAAVLCPS FYRAQIVTNP TRIDKLRQRL RDGVIGFLQR
RDAARRTRLA F
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