ID F8GSV2_CUPNN Unreviewed; 753 AA.
AC F8GSV2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Phospholipase D {ECO:0000313|EMBL:AEI79871.1};
DE EC=3.1.4.4 {ECO:0000313|EMBL:AEI79871.1};
GN OrderedLocusNames=CNE_2c09000 {ECO:0000313|EMBL:AEI79871.1};
OS Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453
OS / N-1) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI79871.1, ECO:0000313|Proteomes:UP000006798};
RN [1] {ECO:0000313|EMBL:AEI79871.1, ECO:0000313|Proteomes:UP000006798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1
RC {ECO:0000313|Proteomes:UP000006798};
RX PubMed=21742890; DOI=10.1128/JB.05660-11;
RA Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT "Complete genome sequence of the type strain Cupriavidus necator N-1.";
RL J. Bacteriol. 193:5017-5017(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000798};
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DR EMBL; CP002878; AEI79871.1; -; Genomic_DNA.
DR RefSeq; WP_013952581.1; NC_015723.1.
DR AlphaFoldDB; F8GSV2; -.
DR KEGG; cnc:CNE_2c09000; -.
DR HOGENOM; CLU_011094_0_0_4; -.
DR Proteomes; UP000006798; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0006793; P:phosphorus metabolic process; IEA:UniProt.
DR CDD; cd09140; PLDc_vPLD1_2_like_bac_1; 1.
DR CDD; cd09143; PLDc_vPLD1_2_like_bac_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR015679; PLipase_D_fam.
DR InterPro; IPR032816; VTT_dom.
DR PANTHER; PTHR18896:SF76; PHOSPHOLIPASE; 1.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AEI79871.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 151..178
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 372..394
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 81707 MW; FA6EDBDD3BCF0176 CRC64;
MRQHNPPGTT APPATGPPHD CQAPLGFTPE PGRNCWRVES CQRFAMLVDA DAYFRALREA
LPRAEHTIFI LGWDIDSRME LVPQGAQDGL PAGLRDFLCA LADQRPELRI YILSWDYAMV
MAMEREWLPS ASAHWQAHRH LSFRLDGNHP PGASHHQKVV VIDNKLAFVG GLDLTLRRWD
DSCHAPGAPL RVAEGKPYPP FHDVQCALDG PAAAALGTLC AARWLRASGS QPRPVAATSS
DPWPPGLAPE LTDVRVAIAR TMPMCEDEPG VSEIRMLLRD AIASARHSIY MENQYFSSHE
IAKALEARLG HEDGPVIVLV SRRNESGWLE AHSMGVLRAR LYRRLRAADT QERFCLYCPS
IPGLMPECVN VHSKVTVIDD DLITIGSSNL SNRSLGLDTE CNIVVMSGGD PRVQAAIAAM
RARLLGEHLD VAPEAFQAEV AATRSVLAAI RNLQRADGRS LEAYEPPLPD DVDAASPAAS
LLDPIEPIDS DQVLAEFVSH EARPRVLGRV GMMVALALLL AGLAFAWRHT PLREWADFRA
LLSVVEQLDE MPLAPLAMIG VYLAGAVTML PVTLLILVTV VIFGPLYGAA LALCGTVLST
GAGYLAGRLL GRNAVRRFGG RRLNRVSHQL GKHGVVAMVV LRLVPIAPFA LVNLVIGASR
ISLRDCLLGT ALGMLPSIVV AACLVNRVAA AARDPGLFTF ALLALVLLVP ASLLLVLRRR
RRRRAEGGAA RPQDDPPGPR GRLARLAALR RQA
//
