ID F8GTF2_CUPNN Unreviewed; 154 AA.
AC F8GTF2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=siroheme decarboxylase {ECO:0000256|ARBA:ARBA00023471};
DE EC=4.1.1.111 {ECO:0000256|ARBA:ARBA00023471};
GN Name=nirG {ECO:0000313|EMBL:AEI81198.1};
GN OrderedLocusNames=CNE_2c22490 {ECO:0000313|EMBL:AEI81198.1};
OS Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453
OS / N-1) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI81198.1, ECO:0000313|Proteomes:UP000006798};
RN [1] {ECO:0000313|EMBL:AEI81198.1, ECO:0000313|Proteomes:UP000006798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1
RC {ECO:0000313|Proteomes:UP000006798};
RX PubMed=21742890; DOI=10.1128/JB.05660-11;
RA Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT "Complete genome sequence of the type strain Cupriavidus necator N-1.";
RL J. Bacteriol. 193:5017-5017(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2;
CC Xref=Rhea:RHEA:19093, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:60052, ChEBI:CHEBI:140497; EC=4.1.1.111;
CC Evidence={ECO:0000256|ARBA:ARBA00023409};
CC -!- PATHWAY: Porphyrin-containing compound metabolism.
CC {ECO:0000256|ARBA:ARBA00023444}.
CC -!- SIMILARITY: Belongs to the Ahb/Nir family.
CC {ECO:0000256|ARBA:ARBA00023457}.
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DR EMBL; CP002878; AEI81198.1; -; Genomic_DNA.
DR RefSeq; WP_013953872.1; NC_015723.1.
DR AlphaFoldDB; F8GTF2; -.
DR KEGG; cnc:CNE_2c22490; -.
DR HOGENOM; CLU_112007_1_0_4; -.
DR Proteomes; UP000006798; Chromosome 2.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.2890; -; 1.
DR Gene3D; 3.30.70.3460; -; 1.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR040523; AsnC_trans_reg2.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43413:SF1; SIROHEME DECARBOXYLASE NIRL SUBUNIT; 1.
DR PANTHER; PTHR43413; TRANSCRIPTIONAL REGULATOR, ASNC FAMILY; 1.
DR Pfam; PF17805; AsnC_trans_reg2; 1.
DR Pfam; PF13404; HTH_AsnC-type; 1.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 8..51
FT /note="HTH asnC-type"
FT /evidence="ECO:0000259|Pfam:PF13404"
FT DOMAIN 74..146
FT /note="Siroheme decarboxylase AsnC-like ligand binding"
FT /evidence="ECO:0000259|Pfam:PF17805"
SQ SEQUENCE 154 AA; 16685 MW; 9CBF85458987E241 CRC64;
MTRPIAALDP LDRRIINALQ RGLPLVPHPY AEAASALGIT EAELLERLRA LLAAGVLTRV
GPLYQIERAG GSFVLCACHT PAERIEAVIA AVNAHPEVAH HYARTHHLNL WFVLAVARPG
EVAPVLARIA AAAGVEILPF PKEREFFVNL YLPA
//
