ID F8GUM9_CUPNN Unreviewed; 358 AA.
AC F8GUM9;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=L-threonine 3-dehydrogenase Tdh {ECO:0000313|EMBL:AEI82433.1};
DE EC=1.1.1.103 {ECO:0000313|EMBL:AEI82433.1};
GN Name=tdh {ECO:0000313|EMBL:AEI82433.1};
GN OrderedLocusNames=CNE_BB1p10250 {ECO:0000313|EMBL:AEI82433.1};
OS Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453
OS / N-1) (Ralstonia eutropha).
OG Plasmid pBB1 {ECO:0000313|EMBL:AEI82433.1,
OG ECO:0000313|Proteomes:UP000006798}.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1042878 {ECO:0000313|EMBL:AEI82433.1, ECO:0000313|Proteomes:UP000006798};
RN [1] {ECO:0000313|EMBL:AEI82433.1, ECO:0000313|Proteomes:UP000006798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1
RC {ECO:0000313|Proteomes:UP000006798};
RC PLASMID=pBB1 {ECO:0000313|EMBL:AEI82433.1,
RC ECO:0000313|Proteomes:UP000006798};
RX PubMed=21742890; DOI=10.1128/JB.05660-11;
RA Poehlein A., Kusian B., Friedrich B., Daniel R., Bowien B.;
RT "Complete genome sequence of the type strain Cupriavidus necator N-1.";
RL J. Bacteriol. 193:5017-5017(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP002879; AEI82433.1; -; Genomic_DNA.
DR RefSeq; WP_013959465.1; NC_015727.1.
DR AlphaFoldDB; F8GUM9; -.
DR KEGG; cnc:CNE_BB1p10250; -.
DR HOGENOM; CLU_026673_11_0_4; -.
DR Proteomes; UP000006798; Plasmid pBB1.
DR GO; GO:0008743; F:L-threonine 3-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43401:SF2; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AEI82433.1}; Plasmid {ECO:0000313|EMBL:AEI82433.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..137
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 179..306
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 358 AA; 37374 MW; 37AAF31958362E7D CRC64;
MLALRKCEPV RGLALTDVEP RQECGPGEVL VKVYATGICG SDLHIDDWHE GTLGWLRQSL
PVTLGHEFSG IVVQAGSDVA NLSPGMGVVV QPALYCGQCA ACAAGRSDLC GSIGFVGITR
DGAFSETVVV PAANCYAVPE GTDLALAALA EPLCVARNAL NTGEVLDEAT VLVLGPGTIG
QGIALQAKLN GARTVIVAGL NDGPRLRRCL ALGIDHVIDL AEDSLQDAIR RITGGQVDRV
FEATGAPGSI GDALSVLRTG GILTCSGIHF DSAAVDISML VRRRLQIRGA YSSVPADWTH
VLGLLATHGE RFRPMITHHL PLDRVLEGFA LARTKDVSKV LVYPGGPDTL TAPTLPVS
//
