ID F8HD82_STRE5 Unreviewed; 460 AA.
AC F8HD82;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN Name=aceF {ECO:0000313|EMBL:AEJ53434.1};
GN OrderedLocusNames=Ssal_01136 {ECO:0000313|EMBL:AEJ53434.1};
OS Streptococcus salivarius (strain 57.I).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1046629 {ECO:0000313|EMBL:AEJ53434.1, ECO:0000313|Proteomes:UP000000293};
RN [1] {ECO:0000313|EMBL:AEJ53434.1, ECO:0000313|Proteomes:UP000000293}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=57.I {ECO:0000313|EMBL:AEJ53434.1,
RC ECO:0000313|Proteomes:UP000000293};
RX PubMed=21914897; DOI=10.1128/JB.05670-11;
RA Geng J., Huang S.C., Li S., Hu S., Chen Y.Y.;
RT "Complete genome sequence of the ureolytic Streptococcus salivarius strain
RT 57.I.";
RL J. Bacteriol. 193:5596-5597(2011).
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; CP002888; AEJ53434.1; -; Genomic_DNA.
DR AlphaFoldDB; F8HD82; -.
DR KEGG; stf:Ssal_01136; -.
DR PATRIC; fig|1046629.4.peg.991; -.
DR eggNOG; COG0508; Bacteria.
DR OMA; TIKQKPW; -.
DR Proteomes; UP000000293; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 2.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 2.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 2..77
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 124..161
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT DOMAIN 166..203
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 460 AA; 48982 MW; 43905842B3BB6634 CRC64;
MAFEIIMPKL GVDMQEGEII EWKKQEGDVV NEGDILLEIM SDKTNMELEA EDSGVLLKIT
RQAGETVPVT EVIGYIGAEG EVVADNVASA PAAEPTTKVE EVATVEAPVV ATQAPVVHEG
GKVRATPKAR KVARELGIDL TQVPGTGAKG RVHADDVENF KGAQPKATPL ARKIAADLGI
DLASVSGTGF GGKITKEDIL AISAPAQVKE AAAAPVVEAK PEKVLPEGVE VIPMSAMRKA
ISKGMTHSYL TAPTFTLNYD VDMTNLMALR KQILDPIMNK TGMKVTFTDL IGLAVVRTLM
KEEHRYINAS LIDDAQNIEL HKFVNLGIAV GLDDGLIVPV VHGADKMSLS EFVVASKDVI
KKAQAGKLKA AEMSGSTFSI TNLGMFGTKS FNPIINQPNS AILGVSATIQ TPVVVDGEVV
VRPIMGLCLT IDHRIVDGMN GAKFMVDLKH LIENPMELLI
//