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Database: UniProt
Entry: F8HD82_STRE5
LinkDB: F8HD82_STRE5
Original site: F8HD82_STRE5 
ID   F8HD82_STRE5            Unreviewed;       460 AA.
AC   F8HD82;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   Name=aceF {ECO:0000313|EMBL:AEJ53434.1};
GN   OrderedLocusNames=Ssal_01136 {ECO:0000313|EMBL:AEJ53434.1};
OS   Streptococcus salivarius (strain 57.I).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1046629 {ECO:0000313|EMBL:AEJ53434.1, ECO:0000313|Proteomes:UP000000293};
RN   [1] {ECO:0000313|EMBL:AEJ53434.1, ECO:0000313|Proteomes:UP000000293}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=57.I {ECO:0000313|EMBL:AEJ53434.1,
RC   ECO:0000313|Proteomes:UP000000293};
RX   PubMed=21914897; DOI=10.1128/JB.05670-11;
RA   Geng J., Huang S.C., Li S., Hu S., Chen Y.Y.;
RT   "Complete genome sequence of the ureolytic Streptococcus salivarius strain
RT   57.I.";
RL   J. Bacteriol. 193:5596-5597(2011).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|ARBA:ARBA00001938,
CC         ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP002888; AEJ53434.1; -; Genomic_DNA.
DR   AlphaFoldDB; F8HD82; -.
DR   KEGG; stf:Ssal_01136; -.
DR   PATRIC; fig|1046629.4.peg.991; -.
DR   eggNOG; COG0508; Bacteria.
DR   OMA; TIKQKPW; -.
DR   Proteomes; UP000000293; Chromosome.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06849; lipoyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 2.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR   PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR   SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 2.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003423};
KW   Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW   Transferase {ECO:0000256|RuleBase:RU003423}.
FT   DOMAIN          2..77
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50968"
FT   DOMAIN          124..161
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
FT   DOMAIN          166..203
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
SQ   SEQUENCE   460 AA;  48982 MW;  43905842B3BB6634 CRC64;
     MAFEIIMPKL GVDMQEGEII EWKKQEGDVV NEGDILLEIM SDKTNMELEA EDSGVLLKIT
     RQAGETVPVT EVIGYIGAEG EVVADNVASA PAAEPTTKVE EVATVEAPVV ATQAPVVHEG
     GKVRATPKAR KVARELGIDL TQVPGTGAKG RVHADDVENF KGAQPKATPL ARKIAADLGI
     DLASVSGTGF GGKITKEDIL AISAPAQVKE AAAAPVVEAK PEKVLPEGVE VIPMSAMRKA
     ISKGMTHSYL TAPTFTLNYD VDMTNLMALR KQILDPIMNK TGMKVTFTDL IGLAVVRTLM
     KEEHRYINAS LIDDAQNIEL HKFVNLGIAV GLDDGLIVPV VHGADKMSLS EFVVASKDVI
     KKAQAGKLKA AEMSGSTFSI TNLGMFGTKS FNPIINQPNS AILGVSATIQ TPVVVDGEVV
     VRPIMGLCLT IDHRIVDGMN GAKFMVDLKH LIENPMELLI
//
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