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Database: UniProt
Entry: F8HZH9_WEIKK
LinkDB: F8HZH9_WEIKK
Original site: F8HZH9_WEIKK 
ID   F8HZH9_WEIKK            Unreviewed;       542 AA.
AC   F8HZH9;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   20-DEC-2017, entry version 43.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:AEJ24186.1};
DE            EC=1.1.1.38 {ECO:0000313|EMBL:AEJ24186.1};
GN   OrderedLocusNames=WKK_06580 {ECO:0000313|EMBL:AEJ24186.1};
OS   Weissella koreensis (strain KACC 15510).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Leuconostocaceae;
OC   Weissella.
OX   NCBI_TaxID=1045854 {ECO:0000313|EMBL:AEJ24186.1, ECO:0000313|Proteomes:UP000008930};
RN   [1] {ECO:0000313|EMBL:AEJ24186.1, ECO:0000313|Proteomes:UP000008930}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KACC 15510 {ECO:0000313|EMBL:AEJ24186.1,
RC   ECO:0000313|Proteomes:UP000008930};
RX   PubMed=21914863; DOI=10.1128/JB.05704-11;
RA   Lee S.H., Jung J.Y., Lee S.H., Jeon C.O.;
RT   "Complete genome sequence of Weissella koreensis KACC 15510, isolated
RT   from Kimchi.";
RL   J. Bacteriol. 193:5534-5534(2011).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003427}.
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DR   EMBL; CP002899; AEJ24186.1; -; Genomic_DNA.
DR   RefSeq; WP_013989857.1; NC_015759.1.
DR   STRING; 1045854.WKK_06580; -.
DR   EnsemblBacteria; AEJ24186; AEJ24186; WKK_06580.
DR   KEGG; wko:WKK_06580; -.
DR   eggNOG; ENOG4105C6K; Bacteria.
DR   eggNOG; COG0281; LUCA.
DR   KO; K22212; -.
DR   OMA; KVLDYAY; -.
DR   OrthoDB; POG091H06EK; -.
DR   BioCyc; WKOR1045854:GH3T-1381-MONOMER; -.
DR   Proteomes; UP000008930; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008930};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003427};
KW   Oxidoreductase {ECO:0000313|EMBL:AEJ24186.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008930}.
FT   DOMAIN       69    251       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      261    517       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE     92     92       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    165    165       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       236    236       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       237    237       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       260    260       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   542 AA;  58926 MW;  48C1E4910435EA40 CRC64;
     MNTKGYDILR NQFLNKGTAF TMEERAELGL IGALPSKVQT LEEQTEQAYK QFQSKSPLLE
     KRIFLMNLFN ENVTLFYNLM DQHVSEFMPI VYDPVVADSI EQYNEIYTNP QNAAFLSVDR
     PEDIESALKN ASDGRDIKLV VVTDAEGILG MGDWGVNGVD IAVGKLMVYT AAAGIDPASV
     LPISIDAGTN NKALLENPLY LGNKHERIAG DEYLAFIDKF VAAEQKLFPE SLLHWEDFGR
     ANAQVILDKY KNNIATFNDD IQGTGMIVLA GIFGALNISK EKLVDQTFVT FGAGSAGMGI
     ANQIFSELKQ AGLSDDEARS HFYLVDKQGL LFDDTEGLTE AQKPFTRSRK EFANADQLTD
     LEAVVNEIHP TVLIGTSTQP GAFTESIVKS MAAHTERPII FPLSNPTKLI EASAENLIKW
     TDGKALIATG IPSDDVEYNG VTYTIGQGNN ALIYPGLGFG LVAATAKLLT PETISAAIHA
     LGGLVDADEA GAAVLPPVSN LTEFSQKIAE VTAQSVVDQD LNREPIADVK QAVQDAKWSA
     EY
//
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