ID F8J2D9_DRYCN Unreviewed; 108 AA.
AC F8J2D9;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE SubName: Full=Putative long chain neurotoxin 346 {ECO:0000313|EMBL:ACR78479.1};
OS Drysdalia coronoides (White-lipped snake) (Hoplocephalus coronoides).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Notechinae; Drysdalia.
OX NCBI_TaxID=66186 {ECO:0000313|EMBL:ACR78479.1};
RN [1] {ECO:0000313|EMBL:ACR78479.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:ACR78479.1};
RX PubMed=21133350; DOI=10.1021/pr1008916;
RA Chatrath S.T., Chapeaurouge A., Lin Q., Lim T.K., Dunstan N., Mirtschin P.,
RA Kumar P.P., Kini R.M.;
RT "Identification of novel proteins from the venom of a cryptic snake
RT Drysdalia coronoides by a combined transcriptomics and proteomics
RT approach.";
RL J. Proteome Res. 10:739-750(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; FJ752457; ACR78479.1; -; mRNA.
DR AlphaFoldDB; F8J2D9; -.
DR TopDownProteomics; F8J2D9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:InterPro.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; CD59; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 2: Evidence at transcript level;
KW Acetylcholine receptor inhibiting toxin {ECO:0000256|ARBA:ARBA00022945};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel impairing toxin {ECO:0000256|ARBA:ARBA00022872};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699, ECO:0000313|EMBL:ACR78479.1};
KW Postsynaptic neurotoxin {ECO:0000256|ARBA:ARBA00023327};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Toxin {ECO:0000256|ARBA:ARBA00022699, ECO:0000313|EMBL:ACR78479.1}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..108
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003378547"
SQ SEQUENCE 108 AA; 12240 MW; 3790C7EC7C481655 CRC64;
MKTLLLTLVV VTIVCLDLAY TRKCYKTHPY KSEPCASGEN LCYTKTWCDF RCSRLGKAVE
LGCAATCPTT KPYEEVTCCS TDDCNRFPNW ERPRPRPRGL LSSITDHP
//
